ArticleTranslational psychiatry2023
Clinical EEG slowing induced by electroconvulsive therapy is better described by increased frontal aperiodic activity.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06725836 (Clinical Testing and Assessment of the Physiological Effects of Invasive Spinal Cord Stimulation Using Electroencephalography to Optimize Rehabilitation Programs and Develop Personalized Approaches for Recovery After Spinal Injury), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Clinical Testing and Assessment of the Physiological Effects of Invasive Spinal Cord Stimulation Using Electroencephalography to Optimize Rehabilitation Programs and Develop Personalized Approaches for Recovery After Spinal Injury
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Subtyping depression using brain-gastric electrophysiology for early prediction of antidepressant response: a multicentric clinical study.Frontiers in psychiatry · 2026Trial
- A pilot safety and tolerability study of scanning ultrasound as a neuromodulation therapy in Alzheimer's disease.Brain communications · 2025Trial
- Brain rhythms of depression: A predictive processing perspective.Trends in neurosciences · 2026Review
- Potential mechanisms and functional significance of aperiodic neural activity.Nature human behaviour · 2026Review
- Aperiodic Brain Activity Modulates Corticospinal Excitability.Neuroscience bulletin · 2026Article
- Dissociating Contributions of Theta and Alpha Oscillations from Aperiodic Neural Activity in Human Visual Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Characteristics of resting-state EEG after deep brain stimulation in nucleus accumbens and anterior limb of internal capsule: a pilot study.BMC psychiatry · 2026Article
- Age-Related Differences and Effects of Internalizing Symptoms on Aperiodic Neural Activity in Adolescents.Psychophysiology · 2026Article
- Analysis of aperiodic activity in obsessive-compulsive disorder and major depression.Scientific reports · 2025Article
- Alterations in aperiodic neural activity associated with major depressive disorder.Nature. Mental health · 2025Article
- Periodic and Aperiodic Alterations of Resting-State EEG in Schizophrenia Spectrum Disorders: Cognitive and Clinical Insights.The European journal of neuroscience · 2025Article
- Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.Nature communications · 2025Article
- Analyzing the Elephant: The Search for Electroencephalography Biomarkers.Biological psychiatry global open science · 2025Article
- Neurophysiological avenues to better conceptualizing adaptive cognition.Communications biology · 2024Article
- Changes in electrophysiological aperiodic activity during cognitive control in Parkinson's disease.Brain communications · 2024Article
- Magnetic seizure therapy and electroconvulsive therapy increase aperiodic activity.Translational psychiatry · 2023Article
- Magnetic seizure therapy and electroconvulsive therapy increase aperiodic activity.medRxiv : the preprint server for health sciences · 2023Article
- Resting-state EEG signatures of Alzheimer's disease are driven by periodic but not aperiodic changes.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Electroconvulsive therapy (ECT) is one of the most efficacious interventions for treatment-resistant depression. Despite its efficacy, ECT's neural mechanism of action remains unknown. Although ECT has been associated with "slowing" in the electroencephalogram (EEG), how this change relates to clinical improvement is unresolved. Until now, increases in slow-frequency power have been assumed to indicate increases in slow oscillations, without considering the contribution of aperiodic activity, a process with a different physiological mechanism. In this exploratory study of nine MDD patients, we show that aperiodic activity, indexed by the aperiodic exponent, increases with ECT treatment. This increase better explains EEG "slowing" when compared to power in oscillatory peaks in the delta (1-3 Hz) range and is correlated to clinical improvement. In accordance with computational models of excitation-inhibition balance, these increases in aperiodic exponent are linked to increasing levels of inhibitory activity, suggesting that ECT might ameliorate depressive symptoms by restoring healthy levels of inhibition in frontal cortices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.