Evidence map›Paper›PMID 37968087›Full record

ArticleArchives of disease in childhood. Fetal and neonatal edition2024

Characteristics and outcomes of neonates hospitalised with SARS-CoV-2 infection in the UK by variant: a prospective national cohort study.

Chris Gale, Don Sharkey, Kathryn E Fitzpatrick, Helen Mactier, Alessandra Morelli, Mariko Nakahara, Madeleine Hurd, Anna Placzek, Marian Knight, Shamez N Ladhani and 5 more

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In one paragraph

Article in Archives of disease in childhood. Fetal and neonatal edition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chris Gale *School of Public Health, Faculty of Medicine, Imperial College of Science Technology and Medicine, London, UK christopher.gale@imperial.ac.uk.ORCID http://orcid.org/0000-0003-0707-876X
Don Sharkey *Academic Child Health, School of Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-4989-8697
Kathryn E FitzpatrickNuffield Department of Population Health, University of Oxford, Oxford, UK.
Helen MactierNeonatology, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0001-6154-5758
Alessandra MorelliNational Perinatal Epidemiology Unit, Oxford University, Oxford, UK.
Mariko NakaharaNational Perinatal Epidemiology Unit, Oxford University, Oxford, UK.
Madeleine HurdNational Perinatal Epidemiology Unit, Oxford University, Oxford, UK.
Anna PlaczekNational Perinatal Epidemiology Unit, Oxford University, Oxford, UK.
Marian KnightNational Perinatal Epidemiology Unit, Oxford University, Oxford, UK.ORCID http://orcid.org/0000-0002-1984-4575
Shamez N LadhaniUK Health Security Agency, London, UK.ORCID http://orcid.org/0000-0002-0856-2476
Elizabeth S DraperHealth Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0001-9340-8176
Cora DohertyNeonatology, University Hospital of Wales, Cardiff, UK.
Maria A QuigleyNational Perinatal Epidemiology Unit, Oxford University, Oxford, UK.
Jennifer J KurinczukNational Perinatal Epidemiology Unit, Oxford University, Oxford, UK.
Neonatal complications of COVID-19 Collaborative Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNeonatal infection with wildtype SARS-CoV-2 is rare and good outcomes predominate. We investigated neonatal outcomes using national population-level data to describe the impact of different SARS-CoV-2 variants.

designProspective population-based cohort study.

settingNeonatal, paediatric and paediatric intensive care inpatient care settings in the UK. PATIENTS: Neonates (first 28 days after birth) with confirmed SARS-CoV-2 infection who received inpatient care, March 2020 to April 2022. Neonates were identified through active national surveillance with linkage to national SARS-CoV-2 testing data, routinely recorded neonatal data, paediatric intensive care data and obstetric and perinatal mortality surveillance data. OUTCOMES: Presenting signs, clinical course, severe disease requiring respiratory support are presented by the dominant SARS-CoV-2 variant in circulation at the time.

results344 neonates with SARS-CoV-2 infection received inpatient care; breakdown by dominant variant: 146 wildtype, 123 alpha, 57 delta and 18 omicron. Overall, 44.7% (153/342) neonates required respiratory support; short-term outcomes were good with 93.6% (322/344) of neonates discharged home. Eleven neonates died: seven unrelated to SARS-CoV-2 infection, four were attributed to neonatal SARS-CoV-2 infection (case fatality 4/344, 1.2% 95% CI 0.3% to 3.0%) of which three were born preterm due to maternal COVID-19. More neonates were born very preterm (23/54) and required invasive ventilation (27/57) when delta variant was predominant, and all four SARS-CoV-2-related deaths occurred in this period.

conclusionsInpatient care for neonates with SARS-CoV-2 was uncommon. Although rare, severe neonatal illness was more common during the delta variant period, potentially reflecting more severe maternal disease and associated preterm birth. TRIAL REGISTRATION NUMBER: ISRCTN60033461.

Indexed as

COVID-19Pregnancy Complications, InfectiousPremature BirthChildCohort StudiesCOVID-19 TestingFemaleHumansInfant, NewbornPregnancyProspective StudiesSARS-CoV-2United KingdomCOVID-19epidemiologyneonatology

Identifiers

PMID37968087
PMCPMC11041575

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.