Evidence map›Paper›PMID 37968012›Full record

ArticleBMJ open2023

REVISE:

Adam M Deane, Waleed Alhazzani, Gordon Guyatt, Simon Finfer, John C Marshall, John Myburgh, Nicole Zytaruk, Miranda Hardie, Lois Saunders, Serena Knowles and 22 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03374800 (Re-EValuating the Inhibition of Stress Erosions), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03374800 phase3completednot on this map

Re-EValuating the Inhibition of Stress Erosions: Prophylaxis Against Gastrointestinal Bleeding in the Critically Ill (The REVISE) Trial

TypeinterventionalSponsorMcMaster UniversityRan2018 to 2024Enrolled4,800ConditionsGastrointestinal Hemorrhage (Clinically Important, Upper)ArmsPlacebo (0.9% saline), Pantoprazole
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Risk Factors for Patient-Important Upper Gastrointestinal Bleeding.American journal of respiratory and critical care medicine · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 17 institutions in 8 countries.

Adam M DeaneDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-7620-5577
Waleed AlhazzaniDepartments of Medicine and Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-8076-9626
Gordon GuyattDepartment of Health Research Methods, Evidence & Impact, Mcmaster University, Hamilton, Ontario, Canada.
Simon FinferCritical Care Program, The George Institute for Global Health, Sydney, New South Wales, Australia.ORCID 0000-0002-2785-5864
John C MarshallInterdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.
John MyburghCritical Care Program, The George Institute for Global Health, Sydney, New South Wales, Australia.ORCID 0000-0003-4088-7016
Nicole ZytarukDepartment of Health Research Methods, Evidence & Impact, Mcmaster University, Hamilton, Ontario, Canada.
Miranda HardieCritical Care Program, The George Institute for Global Health, Sydney, New South Wales, Australia.
Lois SaundersResearch Institute, St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
Serena KnowlesCritical Care Program, The George Institute for Global Health, Sydney, New South Wales, Australia.
Francois LauzierDepartments of Anesthesiology, Medicine & Critical Care Medicine, Centre de Recherche du CHU de Québec - Université Laval, Laval, Quebec, Canada.ORCID 0000-0002-6530-5513
Marianne J ChapmanDiscipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.
Shane EnglishDivision of Critical Care, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.ORCID 0000-0002-9477-6146
John MuscedereDepartment of Critical Care Medicine, Queens University, Kingston, Ontario, Canada.ORCID 0000-0002-9027-7198
Yaseen ArabiIntensive Care Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.ORCID 0000-0001-5735-6241
Marlies OstermannDepartment of Critical Care, King's College London, Guy's & St Thomas' Hospital, London, UK.
Balasubramanian VenkateshCritical Care Program, The George Institute for Global Health, Newtown, New South Wales, Australia.
Paul YoungIntensive Care Department, Wellington Hospital, London, UK.ORCID 0000-0002-3428-3083
Lehana ThabaneDepartment of Health Research Methods, Evidence & Impact, Mcmaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-0355-9734
Laurent BillotStatistics Division, The George Institute for Global Health, Newtown, New South Wales, Australia.ORCID 0000-0002-4975-9793
Diane Heels-AnsdellDepartment of Health Research Methods, Evidence & Impact, Mcmaster University, Hamilton, Ontario, Canada.
Abdulrahman A Al-FaresDepartments of Anesthesia, Critical Care Medicine and Pain Medicine, Al-Amiri Hospital, Kuwait City, Kuwait.ORCID 0000-0001-9475-7976
Naomi E HammondCritical Care Medicine, The George Institute for Global Health, Newtown, New South Wales, Australia.ORCID 0000-0002-6559-7747
R HallDepartments of Anesthesia, Critical Care and Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
Dorrilyn RajbhandariCritical Care Medicine, The George Institute for Global Health, Newtown, New South Wales, Australia.
Alexis PooleDiscipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.
Daniel JohnsonDepartments of Critical Care and Anesthesia, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Mobeen IqbalIntensive Care Department, Maroof International Hospital, Islamabad, Pakistan.
Gilmar ReisCardresearch-Cardiologia Assistencial e de Pesquisa LTDA, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0002-4847-1034
Feng XieDepartment of Health Research Methods, Evidence & Impact, Mcmaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-3454-6266
Deborah J CookDepartments of Medicine and Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada debcook@mcmaster.ca.ORCID 0000-0002-4087-543X
Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group
The George Institute for Global Health · AUImpact · CAThe University of Adelaide · AUAmiri Hospital · KWDalhousie University · CAKing Abdullah International Medical Research Center · SAPontifícia Universidade Católica de Minas Gerais · BRQueen's University · CAShifa International Hospital · PKSt. Joseph’s Healthcare Hamilton · CASt Thomas' Hospital · GBThe University of Melbourne · AUThe Wellington Hospital · GBUniversité Laval · CAUniversity of Nebraska Medical Center · USUniversity of Ottawa · CAUniversity of Toronto · CA

Funding

Department of Health CPMS ID 45782
6 · The paper itself

Abstract

introductionThe METHODS AND ANALYSIS: REVISE is an international, randomised, concealed, stratified, blinded parallel-group individual patient trial being conducted in ICUs in Canada, Australia, Saudi Arabia, UK, US, Kuwait, Pakistan and Brazil. Patients≥18 years old expected to remain invasively mechanically ventilated beyond the calendar day after enrolment are being randomised to either 40 mg pantoprazole intravenously or an identical placebo daily while mechanically ventilated in the ICU. The primary efficacy outcome is clinically important upper GI bleeding within 90 days of randomisation. The primary safety outcome is 90-day all-cause mortality. Secondary outcomes include rates of ventilator-associated pneumonia, ETHICS AND DISSEMINATION: All participating centres receive research ethics approval before initiation by hospital, region or country, including, but not limited to - Australia: Northern Sydney Local Health District Human Research Ethics Committee and Mater Misericordiae Ltd Human Research Ethics Committee; Brazil: Comissão Nacional de Ética em Pesquisa; Canada: Hamilton Integrated Research Ethics Board; Kuwait: Ministry of Health Standing Committee for Coordination of Health and Medical Research; Pakistan: Maroof Institutional Review Board; Saudi Arabia: Ministry of National Guard Health Affairs Institutional Review Board: United Kingdom: Hampshire B Research Ethics Committee; United States: Institutional Review Board of the Nebraska Medical Centre. The results of this trial will inform clinical practice and guidelines worldwide. TRIAL REGISTRATION NUMBER: NCT03374800.

Indexed as

Pneumonia, Ventilator-AssociatedProton Pump InhibitorsAdolescentAdultGastrointestinal HemorrhageHumansIntensive Care UnitsPantoprazoleRandomized Controlled Trials as TopicRespiration, ArtificialPantoprazoleProton Pump InhibitorsAdult gastroenterologyAdult intensive & critical careBleeding disorders & coagulopathiesClinical TrialGastroduodenal disease

Identifiers

PMID37968012
PMCPMC10660838
OpenAlexW4388706653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.