Evidence map›Paper›PMID 37968000›Full record

ArticleBMJ open2023

Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR).

Nishant K Mishra, Patrick Kwan, Tomotaka Tanaka, Katharina S Sunnerhagen, Jesse Dawson, Yize Zhao, Shubham Misra, Selena Wang, Vijay K Sharma, Rajarshi Mazumder and 13 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06108102 (International Post Stroke Epilepsy Research Repository to Characterize Post-stroke Epilepsy Population and Their Outcomes), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06108102 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

International Post Stroke Epilepsy Research Repository to Characterize Post-stroke Epilepsy Population and Their Outcomes

Typeobservational_patient_registrySponsorYale UniversityRan2024 to 2029Enrolled8,000ConditionsPost Stroke Epilepsy, Post Stroke Seizure, Stroke, EpilepsyArmsPresence of stroke, either ischemic or hemorrhagic (intracerebral and subarachnoid)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Nishant K MishraDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA nishant.mishra@yale.edu.ORCID 0000-0002-9327-3707
Patrick KwanDepartment of Neuroscience, Monash University, Clayton, Victoria, Australia.
Tomotaka TanakaDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
Katharina S SunnerhagenDepartment of Clinical Neuroscience, University of Gothenburg, Goteborg, Västra Götaland, Sweden.ORCID 0000-0002-5940-4400
Jesse DawsonInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Yize ZhaoDepartment of Biostatistics, Yale University School of Public Health, New Haven, Connecticut, USA.
Shubham MisraDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-4920-2573
Selena WangDepartment of Biostatistics, Yale University School of Public Health, New Haven, Connecticut, USA.
Vijay K SharmaDivision of Neurology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
Rajarshi MazumderDepartment of Neurology, University of California Los Angeles, Los Angeles, California, USA.
Melissa C FunaroHarvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, Connecticut, USA.
Masafumi IharaDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.ORCID 0000-0002-7102-4048
John-Paul NicoloDepartment of Neuroscience, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-0473-6475
David S LiebeskindDepartment of Neurology, University of California Los Angeles, Los Angeles, California, USA.
Clarissa L YasudaDepartment of Neurology, School of Medical Sciences, University of Campinas - UNICAMP, Campinas, SP, Brazil.
Fernando CendesDepartment of Neurology, School of Medical Sciences, University of Campinas - UNICAMP, Campinas, SP, Brazil.
Terence J QuinnInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Zongyuan GeDepartment of Neuroscience, Monash University, Clayton, Victoria, Australia.
Fabien ScalzoDepartment of Neurology, University of California Los Angeles, Los Angeles, California, USA.
Johan ZelanoDepartment of Clinical Neuroscience, University of Gothenburg, Goteborg, Västra Götaland, Sweden.
Scott E KasnerDepartment of Neurology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
International Post-Stroke Epilepsy Research Consortium (IPSERC)
International Post Stroke Epilepsy Research Consortium (IPSERC)

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

introductionDespite significant advances in managing acute stroke and reducing stroke mortality, preventing complications like post-stroke epilepsy (PSE) has seen limited progress. PSE research has been scattered worldwide with varying methodologies and data reporting. To address this, we established the International Post-stroke Epilepsy Research Consortium (IPSERC) to integrate global PSE research efforts. This protocol outlines an individual patient data meta-analysis (IPD-MA) to determine outcomes in patients with post-stroke seizures (PSS) and develop/validate PSE prediction models, comparing them with existing models. This protocol informs about creating the International Post-stroke Epilepsy Research Repository (IPSERR) to support future collaborative research. METHODS AND ANALYSIS: We utilised a comprehensive search strategy and searched MEDLINE, Embase, PsycInfo, Cochrane, and Web of Science databases until 30 January 2023. We extracted observational studies of stroke patients aged ≥18 years, presenting early or late PSS with data on patient outcome measures, and conducted the risk of bias assessment. We did not apply any restriction based on the date or language of publication. We will invite these study authors and the IPSERC collaborators to contribute IPD to IPSERR. We will review the IPD lodged within IPSERR to identify patients who developed epileptic seizures and those who did not. We will merge the IPD files of individual data and standardise the variables where possible for consistency. We will conduct an IPD-MA to estimate the prognostic value of clinical characteristics in predicting PSE. ETHICS AND DISSEMINATION: Ethics approval is not required for this study. The results will be published in peer-reviewed journals. This study will contribute to IPSERR, which will be available to researchers for future PSE research projects. It will also serve as a platform to anchor future clinical trials. TRIAL REGISTRATION NUMBER: NCT06108102.

Indexed as

EpilepsyStrokeAdolescentAdultHumansMeta-Analysis as TopicPrognosisResearch DesignSeizuresEpilepsyPatient Reported Outcome MeasuresPrognosisStrokeSystematic Review

Identifiers

PMID37968000
PMCPMC10660442

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.