Evidence map›Paper›PMID 37967870›Full record

Observational studyAmerican journal of perinatology2024

Weight Loss, Stability, and Low Weight Gain during Pregnancy among Individuals with Obesity: Associations with Adverse Perinatal Outcomes: An Observational Study.

Elizabeth M Widen, Amy R Nichols, Lorie Harper, Alison Cahill, Jaimie N Davis, Saralyn F Foster, Rachel R Rickman, Fei Xu, Monique M Hedderson

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of perinatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Elizabeth M WidenDepartment of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas.ORCID 0000-0002-9574-6109
Amy R NicholsDepartment of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas.
Lorie HarperDepartment of Women's Health, Dell Medical School, University of Texas at Austin, Austin, Texas.ORCID 0000-0003-0132-2194
Alison CahillDepartment of Women's Health, Dell Medical School, University of Texas at Austin, Austin, Texas.
Jaimie N DavisDepartment of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas.
Saralyn F FosterDepartment of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas.
Rachel R RickmanDepartment of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas.
Fei XuDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Monique M HeddersonDivision of Research, Kaiser Permanente Northern California, Oakland, California.
The University of Texas at Austin · USKaiser Permanente · US

Funding

Population Research CenterR24HD042849 · NICHD · UNIVERSITY OF TEXAS AUSTIN · PI HAYWARD, MARK D. · 2002 to 2016
$8.4M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2M
Cluster randomized trial of a mobile health intervention to achieve appropriate gestational weight gain in overweight/obese womenR01DK118455 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI HEDDERSON, MONIQUE MARIE · 2019 to 2023
$3.0M
Pregnancy weight trajectories and offspring adiposityR00HD086304 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI WIDEN, ELIZABETH MARIE · 2018 to 2020
$744k
Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH R00HD086304Eunice Kennedy Shriver National Institute of Child Health and Human Development P2CHD042849NICHD NIH HHS P2C HD042849NICHD NIH HHS R00 HD086304NICHD NIH HHS R24 HD042849NIDDK NIH HHS R01 DK118455NIDDK NIH HHS R01DK118455
6 · The paper itself

Abstract

objectiveThe safety of weight loss and low weight gain during pregnancy remains unclear. To determine how different patterns of gestational weight gain (GWG), including weight loss, stability, and low GWG relate to perinatal outcomes by prepregnancy obesity class. STUDY

designThe study population included 29,408 singleton livebirths among pregnant people with obesity from Kaiser Permanente Northern California (2008-2013). Clinically measured GWG was grouped into meaningful categories (Adequate: reference, met 2009 National Academy of Medicine [NAM] Guidelines [5-9.1 kg], Excessive [>9.1 kg], Low [1-4.9 kg], Stable [±1 kg], Weight Loss [>1 kg]) or GWG Z-score quintiles. Modified Poisson regression was used to estimate risk of adverse outcomes, stratified by obesity class. Electronic health record data were used to define outcomes, including cesarean delivery, preterm birth, admission to the neonatal intensive care unit, small- and large-for-gestational age infants.

resultsPrevalence of weight stability and weight loss was 3.8 and 3.4%, respectively. Compared with those who gained within NAM, increased risk of small-for-gestational age was observed among those with weight loss among obesity class I (Risk Ratio (RR): 1.57, 95% confidence interval [CI]: 1.12, 2.19), obesity class II (RR: 2.18, 95% CI: 1.52, 3.13), and obesity class III (RR: 1.72, 95% CI: 1.21, 2.45). Weight loss was associated with a decreased risk of cesarean delivery among obesity class III, compared with NAM.

conclusionWeight loss during pregnancy is associated with increased risk of small-for-gestational age among all obesity classes, but not other adverse perinatal outcomes and may reduce risk of cesarean delivery. Low weight gain and weight stability are not associated with risk of adverse outcomes among those with class III obesity. GWG guidelines may need to vary by obesity class. KEY POINTS: · Weight loss during pregnancy is associated with increased risk of small-for-gestational age among all obesity classes; but weight loss was not associated with other adverse perinatal outcomes.. · Among class III, low weight gain and weight stability are not associated with adverse perinatal outcomes.. · GWG guidelines may need to vary by obesity class..

Indexed as

Cesarean SectionGestational Weight GainObesityPregnancy ComplicationsPregnancy OutcomeWeight LossAdultBody Mass IndexCaliforniaFemaleHumansInfant, NewbornInfant, Small for Gestational AgePregnancyPremature BirthYoung Adult

Identifiers

PMID37967870
PMCPMC11193838
OpenAlexW4388713258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.