Evidence map›Paper›PMID 37967214›Full record

ArticleACS chemical neuroscience2023

Fingerprint of Circulating Immunocytes as Biomarkers for the Prognosis of Brain Inflammation and Neuronal Injury after Cardiac Arrest.

Huanyu Dou, Nicole R Brandon, Kerryann E Koper, Yan Xu

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Huanyu DouDepartment of Molecular and Translational Medicine, Paul L. Foster School of Medicine, and Graduate School of Biomedical Sciences, Texas Tech University Health Science Center, El Paso, Texas 79905, United States.
Nicole R BrandonDepartments of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0002-3015-7741
Kerryann E KoperDepartments of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, United States.
Yan XuDepartments of Anesthesiology and Perioperative Medicine, Pharmacology and Chemical Biology, and Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0003-2773-8024
University of Pittsburgh · USTexas Tech University · US

Funding

Injury Mechanisms and Systemic Immune Responses after Cerebral Global IschemiaR01GM114851 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOU, HUANYU, XU, YAN · 2014 to 2017
$1.8M
NIGMS NIH HHS R01 GM114851
6 · The paper itself

Abstract

Cardiac arrest is one of the most dangerous health problems in the world. Outcome prognosis is largely based on cerebral performance categories determined by neurological evaluations. Few systemic tests are currently available to predict survival to hospital discharge. Here, we present the results from the preclinical studies of cardiac arrest and resuscitation (CAR) in mice to identify signatures of circulating immune cells as blood-derived biomarkers to predict outcomes after CAR. Two flow cytometry panels for circulating blood lymphocytes and myeloid-derived cells, respectively, were designed to correlate with neuroinflammation and neuronal and dendritic losses in the selectively vulnerable regions of bilateral hippocampi. We found that CD4

Indexed as

EncephalitisHeart ArrestAnimalsBiomarkersHumansMiceMyeloid CellsPrognosisBiomarkersblood biomarkerscardiac arrest and resuscitationglobal ischemiaperipheral–central immune couplingTreg, polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs)

Identifiers

PMID37967214
PMCPMC10704468
OpenAlexW4388691761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.