Evidence map›Paper›PMID 37967174›Full record

ArticleScience advances2023

Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development.

Justin Malin, Gustavo Ulises Martinez-Ruiz, Yongge Zhao, Susannah C Shissler, Jennifer E Cowan, Yi Ding, Abigail Morales-Sanchez, Masaki Ishikawa, Marieke Lavaert, Arundhoti Das and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Thymus Ontogeny and Development.Advances in experimental medicine and biology · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Justin MalinLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0004-0842-1747
Gustavo Ulises Martinez-RuizLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3555-659X
Yongge ZhaoLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4466-2391
Susannah C ShisslerLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0660-9955
Jennifer E CowanLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Yi DingLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1958-8524
Abigail Morales-SanchezLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Masaki IshikawaLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Marieke LavaertLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Arundhoti DasLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Donna ButcherMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-2065-8067
Andrew C WarnerMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0001-6023-1423
Melissa KallarakalLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Jingqiu ChenOffice of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Noemi KedeiOffice of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Michael KellySingle Cell Analysis Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0654-2778
Lauren R BrinsterDivision of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, MD, USA.
David AllmanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Avinash BhandoolaLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4657-8372
National Institutes of Health · USFrederick National Laboratory for Cancer Research · USOffice of the Director · USNational Cancer Institute · USUniversity of Pennsylvania · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NCI NIH HHS 75N91019D00024
6 · The paper itself

Abstract

Thymic epithelial cells (TEC) control T cell development and play essential roles in establishing self-tolerance. By using

Indexed as

Gene Expression RegulationThymocytesAnimalsCell DifferentiationChromatinEpithelial CellsKruppel-Like Factor 6MiceMice, Inbred C57BLThymus GlandChromatinKlf6 protein, mouseKruppel-Like Factor 6

Identifiers

PMID37967174
PMCPMC10651122
OpenAlexW4388692442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.