ArticleCell reports2023
T cell-specific P2RX7 favors lung parenchymal CD4
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In one paragraph
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- CD39 regulates P2RX7-mediated lung necrotic lesions in severe experimental tuberculosis.Mucosal immunology · 2026Article
- Enhanced tuberculosis control via leveraging dendritic cell-mediated Th1 responses in preventive and immunotherapeutic vaccine strategies.Journal of advanced research · 2026Article
- HIF-1αImmunity · 2026Article
- Regulatory T-cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth.Cancer immunology research · 2026Article
- Identification of Integrated Stress Response-Related Biomarkers in Sepsis-Induced Acute Respiratory Distress Syndrome.Mediators of inflammation · 2026Article
- P2X7 receptor: a potential therapeutic target for chronic respiratory diseases.Molecular and cellular biochemistry · 2026Review
- Impact of Absent in Melanoma 2 (AIM2) on Antigen-Specific CD4+ T cell Activation and Homeostasis.bioRxiv : the preprint server for biology · 2025Article
- VNUT-mediated ATP release suppresses T helper 1 (TScience advances · 2025Article
- Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design.Nature reviews. Immunology · 2025Review
- Risk factors analysis of airway mucus plugs in community-acquired refractory mycoplasma pneumoniae pneumonia: a case-control study.Italian journal of pediatrics · 2025Article
- Aromatic Molecular Compatibility Attenuates Influenza Virus-Induced Acute Lung Injury via the Lung-Gut Axis and Lipid Droplet Modulation.Pharmaceuticals (Basel, Switzerland) · 2025Article
- ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathway.Frontiers in immunology · 2025Article
- Risk factors for pneumonia among children with coinfection of influenza A virus and Mycoplasma pneumoniae.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Location versus ID: what matters to lung-resident memory T cells?Frontiers in immunology · 2024Article
- Tissue- and temporal-specific roles of extracellular ATP on T cell metabolism and function.Immunometabolism (Cobham, Surrey) · 2023Review
- P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis.Frontiers in immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 4 institutions in 3 countries.
Igor Santiago-CarvalhoDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil; Department of Immunology, Mayo Clinic, Scottsdale, AZ 85259, USA.
Gislane Almeida-SantosDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Bruna Gois MacedoDepartment of Immunology, Mayo Clinic, Scottsdale, AZ 85259, USA.
Caio Cesar Barbosa-BomfimDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Fabricio Moreira AlmeidaLaboratory of Biology of Recognition, North Fluminense State University, Campos, RJ 28013-602, Brazil.
Marcos Vinícios Pinheiro CioneDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Trupti Vardam-KaurDepartment of Immunology, Mayo Clinic, Scottsdale, AZ 85259, USA.
Mia MasudaDepartment of Immunology, Mayo Clinic, Scottsdale, AZ 85259, USA.
Sarah Van DijkDepartment of Immunology, Mayo Clinic, Scottsdale, AZ 85259, USA.
Bruno Marcel MeloDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14040-900, Brazil.
Rogério Silva do NascimentoDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Rebeka da Conceição SouzaLaboratory of Biology of Recognition, North Fluminense State University, Campos, RJ 28013-602, Brazil.
Alba Lucínia Peixoto-RangelLaboratory of Biology of Recognition, North Fluminense State University, Campos, RJ 28013-602, Brazil.
Robson Coutinho-SilvaInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
Mario Hiroyuki HirataDepartment of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
José Carlos Alves-FilhoDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14040-900, Brazil.
José Maria ÁlvarezDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Elena LassounskaiaLaboratory of Biology of Recognition, North Fluminense State University, Campos, RJ 28013-602, Brazil.
Henrique Borges da SilvaDepartment of Immunology, Mayo Clinic, Scottsdale, AZ 85259, USA. Electronic address: borgesdasilva.henrique@mayo.edu.
Maria Regina D'Império-LimaDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address: relima@usp.br.
Universidade de São Paulo · BRMayo Clinic in Arizona · USState University of Norte Fluminense · BRUniversidade Federal do Rio de Janeiro · BR
Funding
Control of antiviral memory CD8+ T cell longevity by extracellular ATP sensingR01AI170649 · NIAID · MAYO CLINIC ARIZONA · PI Henrique Borges da Silva · 2022 to 2026
$2.4MDEFINING THE FUNCTION OF EXTRACELLULAR ATP SENSING FOR MEMORY CD8+ T CELL GENERATION AND LONGEVITYR00AI139381 · NIAID · MAYO CLINIC ARIZONA · PI BORGES DA SILVA, HENRIQUE · 2020 to 2021
$498kNIAID NIH HHS R00 AI139381NIAID NIH HHS R01 AI170649
Abstract
CD4
Indexed as
Influenza, HumanTuberculosisAnimalsCD4-Positive T-LymphocytesHumansLungMiceReceptors, ChemokineReceptors, Purinergic P2X7P2rx7 protein, mouseReceptors, ChemokineReceptors, Purinergic P2X7CD4(+) T cellCP: ImmunologyCXCR3extracellular ATPinfluenzalunglung damageP2RX7tuberculosis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.