Evidence map›Paper›PMID 37966664›Full record

ArticleMolecular biotechnology2024

Circular RNA PIP5K1A Promotes Glucose and Lipid Metabolism Disorders and Inflammation in Type 2 Diabetes Mellitus.

Ge Song, YiQian Zhang, YiHua Jiang, Huan Zhang, Wen Gu, Xiu Xu, Jing Yao, ZhengFang Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Role of Triglyceride-Glucose Index in Type 2 Diabetes Mellitus and Its Complications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ge SongDepartment of Endocrinology, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, No. 1 College Street, Suzhou City, Jiangsu Province, 215500, China.
YiQian ZhangDepartment of Endocrinology, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, No. 1 College Street, Suzhou City, Jiangsu Province, 215500, China.
YiHua JiangDepartment of Endocrinology, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, No. 1 College Street, Suzhou City, Jiangsu Province, 215500, China.
Huan ZhangDepartment of Endocrinology, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, No. 1 College Street, Suzhou City, Jiangsu Province, 215500, China.
Wen GuDepartment of Endocrinology, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, No. 1 College Street, Suzhou City, Jiangsu Province, 215500, China.
Xiu XuDepartment of Endocrinology, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, No. 1 College Street, Suzhou City, Jiangsu Province, 215500, China.
Jing YaoDepartment of Endocrinology, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, No. 1 College Street, Suzhou City, Jiangsu Province, 215500, China.
ZhengFang ChenDepartment of Endocrinology, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, No. 1 College Street, Suzhou City, Jiangsu Province, 215500, China. chenzf2213@126.com.ORCID http://orcid.org/0000-0002-8052-1169
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disorders of glucose and lipid metabolism are an important cause of type 2 diabetes mellitus (T2DM). Identifying the molecular mechanism of metabolic disorders is key to the treatment of T2DM. The study was to investigate the effect of circRNA PIP5K1A (circPIP5K1A) on glucose and lipid metabolism and inflammation in T2DM rats. A T2DM rat model was established, and then the T2DM rats were injected with lentiviral vectors that interfere with circPIP5K1A, miR-552-3p, or ENO1 expression. Fasting blood glucose (FBG) and fasting insulin (FINS) levels of rats were detected by an automatic analyzer and insulin detection kit, and HOMA-IR was calculated. Lipid metabolism was assessed by measuring serum levels of TG, TC, LDL-C, leptin, and resistin. Serum levels of inflammatory factors (TNF-α and IL-6) were detected by ELISA. The pathological conditions of pancreatic tissue were observed by HE staining. circPIP5K1A, miR-552-3p and ENO1 levels were recorded. The experimental results showed that circPIP5K1A and ENO1 were up-regulated, and miR-552-3p was down-regulated in T2DM rats. Down-regulating circPIP5K1A or up-regulating miR-552-3p reduced blood glucose and lipid levels, inhibited inflammation, and improved pancreatic histopathological changes in T2DM rats. In addition, up-regulating ENO1 rescued the ameliorating effects of down-regulated circPIP5K1A on T2DM rats. In general, downregulating circPIP5K1A improves insulin resistance and lipid metabolism disorders and inhibits inflammation by targeting miR-552-3p to mediate ENO1 expression.

Indexed as

Diabetes Mellitus, Type 2InflammationLipid MetabolismMicroRNAsRNA, CircularAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalDNA-Binding ProteinsGlucoseInsulinInsulin ResistanceLipid Metabolism DisordersMaleRatsRats, Sprague-DawleyBlood GlucoseDNA-Binding ProteinsGlucoseInsulinMicroRNAsRNA, CircularCircular RNA PIP5K1ADisorder of Glucose and Lipid MetabolismENO1InflammationmiR-552-3pType 2 Diabetes Mellitus

Identifiers

PMID37966664
OpenAlexW4388704657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.