Evidence map›Paper›PMID 37965994›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2024

Patterns of individual compliance with anthelmintic treatment for soil-transmitted helminth infections in southern Ethiopia over six rounds of community-wide mass drug administration.

R Maddren, B Collyer, A E Phillips, S Rayment Gomez, B Abtew, U Anjulo, D Tadele, A Sharma, A Tamiru, E Firdawek Liyew and 2 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

R MaddrenImperial College London, St Mary's Campus, Praed Street, London W2 1NY, UK.ORCID 0000-0001-9363-3103
B CollyerImperial College London, St Mary's Campus, Praed Street, London W2 1NY, UK.
A E PhillipsFHI360, 359 Blackwell Street, Suite 200, Durham, NC, USA.
S Rayment GomezImperial College London, St Mary's Campus, Praed Street, London W2 1NY, UK.
B AbtewImperial College London, St Mary's Campus, Praed Street, London W2 1NY, UK.
U AnjuloFederal Ministry of Health, 1234 Sudan Street, Addis Ababa, Ethiopia.
D TadeleSimprints, Cambridge CB1 2FH, UK.
A SharmaSimprints, Cambridge CB1 2FH, UK.
A TamiruFederal Ministry of Health, 1234 Sudan Street, Addis Ababa, Ethiopia.
E Firdawek LiyewEthiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
M ChernetEthiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
R M AndersonImperial College London, St Mary's Campus, Praed Street, London W2 1NY, UK.
Imperial College London · GBEthiopian Public Health Institute · ETFederal Ministry of Health · ETFamily Health International 360 · US

Funding

Children's Investment Fund Foundation R-1805-02741Medical Research Council MR/R015600/1Medical Research Council MR/X020258/1
6 · The paper itself

Abstract

backgroundThe mainstay of soil-transmitted helminth (STH) control is repeated mass drug administration (MDA) of anthelmintics to endemic populations. Individual longitudinal compliance treatment patterns are important for identifying pockets of infected individuals who remain untreated and serve as infection reservoirs.

methodsThe Geshiyaro Project censused the study population in Wolaita, Ethiopia at baseline in 2018. Individual longitudinal compliance was recorded for six rounds of community-wide MDA (cMDA). The probability distribution of treatment frequency was analysed by age and gender stratifications. Probabilities of transmission interruption for different compliance patterns were calculated using an individual-based stochastic model of Ascaris lumbricoides transmission.

resultsThe never-treated (0.42%) population was smaller than expected from a random positive binomial distribution. The observed compliance frequency was well described by the beta-binomial distribution. Preschool-age children (odds ratio [OR] 10.1 [95% confidence interval {CI} 6.63 to 15.4]) had the highest never-treated proportion of the age groups. Conversely, school-age children (SAC) and adults (OR 1.03 [95% CI 0.98 to 1.09]) had the highest always-treated proportion of the age groups.

conclusionsThe study reports the largest dataset of individual longitudinal compliance to cMDA for STH control. Clear pattens are shown in the age-dependent distribution of individual compliance behaviour. The impact of compliance on the probability of elimination is significant, highlighting the importance of recording the full frequency distribution, not just the never-treated proportion.

Indexed as

AnthelminticsHelminthiasisMass Drug AdministrationSoilAdolescentAdultAnimalsAscaris lumbricoidesChildChild, PreschoolDrug MonitoringEthiopiaFemaleHumansInfantLongitudinal StudiesAnthelminticsSoilcontrol programindividual longitudinal compliancemass drug administrationneglected tropical diseasesnever treatedsoil-transmitted helminthstransmission break

Identifiers

PMID37965994
PMCPMC11062190
OpenAlexW4388706783

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.