ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Association between military service and Alzheimer's disease neuropathology at autopsy.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular alterations in the basolateral amygdala of older Veterans.Neurobiology of aging · 2026Article
- Stewardship Behaviour Among Residents of the Great Barrier Reef Region and the Role of Self-Efficacy.Environmental management · 2026Article
- A novel hierarchical framework elucidating regional differences in α-synuclein and tau co-pathology in military veterans with parkinsonism.Journal of neuropathology and experimental neurology · 2026Article
- Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular remodeling in the amygdala of older Veterans.Research square · 2026Article
- Cognitive decline in U.S. military veterans: risk factors and clinical implications.Frontiers in dementia · 2026Article
- Deriving life-course residential histories in brain bank cohorts: A feasibility study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.Annals of neurology · 2024Review
- Association between military service and Alzheimer's disease neuropathology at autopsy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Mid- and late-life depression increases risk of Alzheimer's disease and related dementias in veterans.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
8 authors.
Funding
Abstract
introductionAnti-amyloid therapies are at the forefront of efforts to treat Alzheimer's disease (AD). Identifying amyloid risk factors may aid screening and intervention strategies. While veterans face increased exposure to risk factors, whether they face a greater neuropathologic amyloid burden is not well understood.
methodsMale decedents donating to two Alzheimer's Disease Research Center (ADRC) brain banks from 1986 to 2018 with categorized neuritic plaque density and neurofibrillary tangles (n = 597) were included. Using generalized ordered logistic regression we modeled each outcome's association with military history adjusting for age and death year.
resultsHaving served in the military (60% of sample) is associated with post mortem neuritic amyloid plaque (for each comparison of higher to lower C scores OR = 1.26; 95% confidence interval [CI] = 1.06-1.49) and tau pathology (B score OR = 1.10; 95% CI = 1.08-1.12). DISCUSSION: This is the first study, to our knowledge, finding increased levels of verified AD neuropathology in those with military service. Targeted veteran AD therapies is a pressing need.
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