Evidence map›Paper›PMID 37965676›Full record

ArticleEuropean endodontic journal2024

In Vitro Evaluation of Smear Layer and Debris Removal and Antimicrobial Activity of Different Irrigating Solutions.

Raffaella Castagnola, Cecilia Martini, Mauro Colangeli, Ilaria Pellicciotta, Luca Marigo, Nicola Maria Grande, Francesca Bugli, Gianluca Plotino

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in European endodontic journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07241650 (Postoperative Pain and Quality of Life in Root Canal Treatment), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07241650 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Postoperative Pain and Quality of Life in Root Canal Treatment: Prospective Study

TypeinterventionalSponsorAnkara Yildirim Beyazıt UniversityRan2025 to 2026Enrolled90ConditionsIrreversible Acute Pulpitis, Root Canal TreatmentArmsIrrigation with Sodium Hypochlorite and Conventional Syringe, Irrigation with Sodium Hypochlorite and EDDY, Procedure: Irrigation with Sodium Hypochlorite and Diode Laser, Procedure: Irrigation with Etidronic Acid and Conventional Syringe, Procedure: Irrigation with Etidronic Acid and EDDY
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Raffaella CastagnolaDepartment of Ageing, Neurological, Orthopaedic, Head and Neck Sciences, A. Gemelli University Polyclinic Foundation IRCCS, UOC General Dentistry and Orthodontics, Rome, Italy; Department of Head-Neck and Sense Organs, Catholic University of the Sacred Heart, Rome, Italy.
Cecilia MartiniDepartment of Basic Biotechnological Sciences, Catholic University of the Sacred Heart, Intensivology and Perioperative Clinics, Rome, Italy.
Mauro ColangeliDepartment of Ageing, Neurological, Orthopaedic, Head and Neck Sciences, A. Gemelli University Polyclinic Foundation IRCCS, UOC General Dentistry and Orthodontics, Rome, Italy; Department of Head-Neck and Sense Organs, Catholic University of the Sacred Heart, Rome, Italy.
Ilaria PellicciottaDepartment of Ageing, Neurological, Orthopaedic, Head and Neck Sciences, A. Gemelli University Polyclinic Foundation IRCCS, UOC General Dentistry and Orthodontics, Rome, Italy; Department of Head-Neck and Sense Organs, Catholic University of the Sacred Heart, Rome, Italy.
Luca MarigoDepartment of Ageing, Neurological, Orthopaedic, Head and Neck Sciences, A. Gemelli University Polyclinic Foundation IRCCS, UOC General Dentistry and Orthodontics, Rome, Italy; Department of Head-Neck and Sense Organs, Catholic University of the Sacred Heart, Rome, Italy.
Nicola Maria GrandeDepartment of Ageing, Neurological, Orthopaedic, Head and Neck Sciences, A. Gemelli University Polyclinic Foundation IRCCS, UOC General Dentistry and Orthodontics, Rome, Italy; Department of Head-Neck and Sense Organs, Catholic University of the Sacred Heart, Rome, Italy.
Francesca BugliDepartment of Basic Biotechnological Sciences, Catholic University of the Sacred Heart, Intensivology and Perioperative Clinics, Rome, Italy; Department of Laboratory and Infectious Sciences, A. Gemelli University Polyclinic Foundation IRCCS, Rome, Italy.
Gianluca PlotinoPrivate Practice, Rome, Italy.
University of the Sacred Heart · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this in vitro study was to compare the smear layer and debris removal and antimicrobial activity of two dual-action irrigating solutions for continuous chelation (Triton; Brasseler, Savannah, USA and Dual Rinse HEDP; Medcem GmbH, Weinfelden, Switzerland) with a dual step irrigation protocol with sodium hypochlorite (NaOCl) followed by ethylenediaminetetraacetic acid (EDTA).

methodsThirty single-rooted single-canal teeth were divided into three groups (n=10) and irrigated with Triton, Dual Rinse HEDP mixed with 6% NaOCl and 6% NaOCl/17% EDTA. The teeth were observed under a scanning electron microscope (SEM) to assess the canal wall cleanliness. In addition, 80 dentine discs were contaminated with Candida albicans and 80 discs with Enterococcus faecalis and irrigated with Triton, Dual Rinse HEDP mixed with 6% NaOCl and 6% NaOCl/17% EDTA or not treated (n=20). Fifteen discs were used to evaluate colony-forming units, while 5 discs were analysed by SEM. Data were analysed using the Shapiro- Wilk, Kruskal-Wallis and One-Way ANOVA tests.

resultsTriton was statistically more effective than Dual Rinse HEDP and NaOCl/EDTA in removing debris (p<0.05), except with NaOCl/EDTA in the coronal third. Triton was more effective than Dual Rinse HEDP in removing the smear layer from the apical and middle thirds (p<0.05). All the irrigation protocols significantly re- duced the number of E. faecalis. The Triton group showed the lowest number of remaining C. albicans (p<0.05).

conclusionTriton was the most effective irrigation solution in removing debris and as effective as NaOCl/ EDTA in removing the smear layer. Triton showed the highest efficacy against C. albicans. New irrigating solutions that provide continuous chelation may provide an alternative to current irrigation protocols.

Indexed as

Anti-Infective AgentsSmear LayerChelating AgentsDental Pulp CavityEdetic AcidEtidronic AcidHumansMicroscopy, Electron, ScanningRoot Canal IrrigantsRoot Canal PreparationAnti-Infective AgentsChelating AgentsEdetic AcidEtidronic AcidRoot Canal Irrigants

Identifiers

PMID37965676
PMCPMC10777091
OpenAlexW4388706774

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.