Evidence map›Paper›PMID 37965492›Full record

ArticleBiology methods & protocols2023

A method for measurement of human asparagine synthetase (ASNS) activity and application to ASNS protein variants associated with ASNS deficiency.

Mario C Chang, Stephen J Staklinski, Matthew E Merritt, Michael S Kilberg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology methods & protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mario C ChangDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, United States.ORCID https://orcid.org/0000-0002-2452-2693
Stephen J StaklinskiDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, United States.ORCID https://orcid.org/0000-0002-1746-6320
Matthew E MerrittDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, United States.ORCID https://orcid.org/0000-0003-4617-9651
Michael S KilbergDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, United States.
University of Florida · USCold Spring Harbor Laboratory · US

Funding

Asparagine Synthetase DeficiencyR21HD100576 · NICHD · UNIVERSITY OF FLORIDA · PI KILBERG, MICHAEL S. · 2020 to 2021
$419k
NICHD NIH HHS R21 HD100576
6 · The paper itself

Abstract

Human asparagine synthetase (ASNS) catalyzes the conversion of aspartate to asparagine in an ATP-dependent reaction that utilizes glutamine as a nitrogen source while generating glutamate, AMP, and pyrophosphate as additional products. Asparagine Synthetase Deficiency (ASNSD) is an inborn error of metabolism in which children present with homozygous or compound heterozygous mutations in the

Indexed as

amino acidsasparagineenzyme assayenzyme deficiencymetabolismneurotransmitterspediatrics

Identifiers

PMID37965492
PMCPMC10641120
OpenAlexW4388262293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.