Evidence map›Paper›PMID 37965489›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2023

Self-emulsifying micelles as a drug nanocarrier system for itraconazole oral bioavailability enhancement;

Nayyer Islam, Naveed Ullah Khan, Anam Razzaq, Zaheer Ullah Khan, Farid Menaa, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Haroon Iqbal, Jiang Ni

Open access · hybridAbstract read
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Nayyer IslamDepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, GC University, Faisalabad, Pakistan.
Naveed Ullah KhanDepartment of Pharmacy, CECOS University of IT and Emerging Sciences, Peshawar 25000, Pakistan.
Anam RazzaqCollege of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
Zaheer Ullah KhanDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan.
Farid MenaaDepartments of Oncology and Nanomedicine, California Innovations Corporation, San Diego, CA 92037, USA.
Mohammad Y AlfaifiKing Khalid University, Faculty of Science, Biology Department, Abha 9004, Saudi Arabia.
Serag Eldin I ElbehairiKing Khalid University, Faculty of Science, Biology Department, Abha 9004, Saudi Arabia.
Haroon IqbalZhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
Jiang NiDepartment of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi 214000, China.
King Khalid University · SACalifornia Medical Innovations Institute · USCECOS University · PKCOMSATS University Islamabad · PKSoochow University · CNWuxi Fourth People's Hospital · CNZhejiang Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Itraconazole (ITZ) is a renowned antifungal medication, however its therapeutic efficacy is limited by low solubility and oral bioavailability. The current research work attempted to augment the oral bioavailability of ITZ by incorporating into self-emulsifying micelles (SEMCs). To fabricate the SEMCs, various preparation techniques including physical mixture, melt-emulsification, solvent evaporation and kneading, were opted by using different weight ratio of drug and solubilizers i.e. Gelucire-50/13 or Gelucire-44/14 and characterized both in vitro and

Indexed as

BioavailabilityDissolution rateGelucire44/14Gelucire 50/13ItraconazoleMicellesSolubility

Identifiers

PMID37965489
PMCPMC10641562
OpenAlexW4388002710

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.