Evidence map›Paper›PMID 37965432›Full record

ArticleEClinicalMedicine2023

Life expectancy and years of potential life lost in people with mental disorders: a systematic review and meta-analysis.

Joe Kwun Nam Chan, Christoph U Correll, Corine Sau Man Wong, Ryan Sai Ting Chu, Vivian Shi Cheng Fung, Gabbie Hou Sem Wong, Janet Hiu Ching Lei, Wing Chung Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 9 pooled it
34.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 9 syntheses or guidelines pooled it, 156 citations in OpenAlex.

  1. Prevalence and Incidence of Dementia for Schizophrenia and Other Primary Psychotic Disorders: A Systematic Review and Meta-Analysis.Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2026
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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Joe Kwun Nam ChanLKS Faculty of Medicine, Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
Christoph U CorrellDepartment of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA.
Corine Sau Man WongLKS Faculty of Medicine, School of Public Health, The University of Hong Kong, Hong Kong, China.
Ryan Sai Ting ChuLKS Faculty of Medicine, Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
Vivian Shi Cheng FungLKS Faculty of Medicine, Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
Gabbie Hou Sem WongLKS Faculty of Medicine, Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
Janet Hiu Ching LeiLKS Faculty of Medicine, Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
Wing Chung ChangLKS Faculty of Medicine, Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
Chinese University of Hong Kong · HKNorthwell Health · USUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mental disorders are associated with premature mortality. There is increasing research examining life expectancy and years-of-potential-life-lost (YPLL) to quantify the disease impact on survival in people with mental disorders. We aimed to systematically synthesize studies to estimate life expectancy and YPLL in people with any and specific mental disorders across a broad spectrum of diagnoses. Methods: In this systematic review and meta-analysis, we searched Embase, MEDLINE, PsychINFO, WOS from inception to July 31, 2023, for published studies reporting life expectancy and/or YPLL for mental disorders. Criteria for study inclusion were: patients of all ages with any mental disorders; reported data on life expectancy and/or YPLL of a mental-disorder cohort relative to the general population or a comparison group without mental disorders; and cohort studies. We excluded non-cohort studies, publications containing non-peer-reviewed data or those restricted to population subgroups. Survival estimates, i.e., life expectancy and YPLL, were pooled (based on summary data extracted from the included studies) using random-effects models. Subgroup analyses and random-effects meta-regression analyses were performed to explore sources of heterogeneity. Risk-of-bias assessment was evaluated using the Newcastle-Ottawa Scale. This study is registered with PROSPERO (CRD42022321190). Findings: Of 35,865 studies identified in our research, 109 studies from 24 countries or regions including 12,171,909 patients with mental disorders were eligible for analysis (54 for life expectancy and 109 for YPLL). Pooled life expectancy for mental disorders was 63.85 years (95% CI 62.63-65.06; Interpretation: Mental disorders are associated with substantially reduced life expectancy, which is transdiagnostic in nature, encompassing a wide range of diagnoses. Implementation of comprehensive and multilevel intervention approaches is urgently needed to rectify lifespan inequalities for people with mental disorders. Funding: None.

Indexed as

Life expectancyMental illnessMeta-analysisPremature mortalityYears of potential life lostYPLL

Identifiers

PMID37965432
PMCPMC10641487
OpenAlexW4388075595

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.