Evidence map›Paper›PMID 37965338›Full record

ArticleFrontiers in immunology2023

RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development.

Thomas Hägglöf, Raksha Parthasarathy, Nathaniel Liendo, Elizabeth A Dudley, Elizabeth A Leadbetter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Thomas Hägglöf *Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health at San Antonio, San Antonio, TX, United States.
Raksha Parthasarathy *Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health at San Antonio, San Antonio, TX, United States.
Nathaniel LiendoDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health at San Antonio, San Antonio, TX, United States.
Elizabeth A DudleyDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health at San Antonio, San Antonio, TX, United States.
Elizabeth A LeadbetterDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health at San Antonio, San Antonio, TX, United States.
The University of Texas Health Science Center at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
UNDERGRADUATE STUDENT TRAINING IN ACADEMIC RESEARCHT34GM008073 · NIGMS · ST. MARY'S UNIVERSITY · PI CONTRERAS-SHANNON, VERONICA E · 1985 to 2022
$5.7M
Innate modulation of autoimmune, regulatory, and effector B cells in adipose tissueR01AI132798 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEADBETTER, ELIZABETH ANN · 2018 to 2022
$1.9M
NCATS NIH HHS UL1 TR001120NCI NIH HHS P30 CA054174NIAID NIH HHS R01 AI132798NIGMS NIH HHS T34 GM008073
6 · The paper itself

Abstract

Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors. Mutations in the scaffolding domain of

Indexed as

Natural Killer T-CellsAnimalsApoptosisCell DeathHumansMiceReceptor-Interacting Protein Serine-Threonine KinasesThymus GlandReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mousecaspase 8iNKT cell developmentNK1.1+ cellsRIPK1RIPK3

Identifiers

PMID37965338
PMCPMC10642909
OpenAlexW4388021820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.