Evidence map›Paper›PMID 37965293›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2023

Investigation of novel bis-thiadiazole bearing schiff base derivatives as effective inhibitors of thymidine phosphorylase: Synthesis, in vitro bioactivity and molecular docking study.

Rafaqat Hussain, Wajid Rehman, Shoaib Khan, Fadi Jaber, Fazal Rahim, Mazloom Shah, Yousaf Khan, Shahid Iqbal, Haseena Naz, Imran Khan and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 5 countries.

Rafaqat HussainDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Wajid RehmanDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Shoaib KhanDepartment of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad, Pakistan.
Fadi JaberDepartment of Biomedical Engineering, Ajman University, Ajman, United Arab Emirates.
Fazal RahimDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Mazloom ShahDepartment of Chemistry, Faculty of Science, Grand Asian University, Sialkot, Pakistan.
Yousaf KhanDepartment of Chemistry, COMSATS University, Islamabad 45550, Pakistan.
Shahid IqbalNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham, Ningbo 315100, China.
Haseena NazDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Imran KhanDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Mohammed Issa AlahmdiDepartment of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
Nasser S AwwadChemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.
Hala A IbrahiumBiology Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.
Hazara University · PKKing Khalid University · SAAbbottabad University of Science and Technology · PKAjman University · AEAsian University · THCOMSATS University Islamabad · PKUniversity of Nottingham Ningbo China · CNUniversity of Tabuk · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymidine phosphorylase (TP) is an angiogenic enzyme. It is crucial for the development, invasion and metastasis of tumors as well as angiogenesis. In our current research, we examine how structurally changing bis-thiadiazole bearing bis-schiff bases affects their ability to inhibit TP. Through the oxidative cyclization of pyridine-based bis-thiosemicarbazone with iodine, a series of fourteen analogs of bis-thiadiazole-based bis-imines with pyridine moiety were developed. Newly synthesized scaffolds were assessed in vitro for their thymidine phosphorylase inhibitory potential and showed moderate to good inhibition profile. Eleven scaffolds such as

Indexed as

Docking studyInhibitorsIn Vitro analysisSAR relationshipSynthesis

Identifiers

PMID37965293
PMCPMC10641276
OpenAlexW4387580712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.