Evidence map›Paper›PMID 37965267›Full record

ArticleFrontiers in cellular and infection microbiology2023

Arthika Manoharan, Jessica Farrell, Vina R Aldilla, Greg Whiteley, Erik Kriel, Trevor Glasbey, Naresh Kumar, Kate H Moore, Jim Manos, Theerthankar Das

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Life (Basel, Switzerland) · 2026
    Review
  3. Redefining the role of the thiol-based agentRSC medicinal chemistry · 2026
    Review
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Unveiling the hidden arsenal: new insights intoFrontiers in cellular and infection microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Arthika ManoharanInfection, Immunity and Inflammation Theme, School of Medical Sciences, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Jessica FarrellInfection, Immunity and Inflammation Theme, School of Medical Sciences, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Vina R AldillaSchool of Chemistry, The University of New South Wales, Sydney, NSW, Australia.
Greg WhiteleyInfection, Immunity and Inflammation Theme, School of Medical Sciences, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Erik KrielWhiteley Corporation, Tomago, NSW, Australia.
Trevor GlasbeyWhiteley Corporation, Tomago, NSW, Australia.
Naresh KumarSchool of Chemistry, The University of New South Wales, Sydney, NSW, Australia.
Kate H MooreDepartment of Urogynaecology, St George Hospital, University of New South Wales, Sydney, NSW, Australia.
Jim ManosInfection, Immunity and Inflammation Theme, School of Medical Sciences, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Theerthankar DasInfection, Immunity and Inflammation Theme, School of Medical Sciences, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
University of Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: To quantify urease activity, Berthelot's method was done on bacterial extracts treated with NAC. We also used an Results: NAC inhibits urease activity of clinical Discussion: Using biochemical, microbiological and immunological techniques, this study displays the functionality of NAC in preventing catheter occlusion by inhibiting urease activity. The study also highlights NAC as a strong anti-inflammatory antibiofilm agent that can target both bacterial and host factors in the treatment of CA-UTIs.

Indexed as

Proteus InfectionsUrinary Tract InfectionsAcetylcysteineAnti-Inflammatory AgentsBiofilmsCathetersHumansInflammationProteus mirabilisUreaseUrinary CatheterizationAcetylcysteineAnti-Inflammatory AgentsUreasebiofilmscatheter-associated urinary tract infections (CA-UTI)N-acetyl cysteine (NAC)Proteus mirabilisureaseUTI

Identifiers

PMID37965267
PMCPMC10641931
OpenAlexW4388178815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.