ArticleFrontiers in cellular and infection microbiology2023
Hyper-inflammatory profile and immunoparalysis in patients with severe Legionnaires' disease.
Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 5 citations in OpenAlex.
- Awake Prone Positioning in Moderate ARDS: A Case Report.Clinics and practice · 2026Article
- A Rare Combination of Legionella ARDS and Pulmonary Embolism: A Case Report.International medical case reports journal · 2026Article
- Review
- Severe Legionnaires' disease.Annals of intensive care · 2024Review
- Inflammatory Patterns Associated withPathogens (Basel, Switzerland) · 2024Article
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Authors and funding
23 authors at 9 institutions in 1 country.
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Abstract
Introduction: Severe Legionnaires' disease (LD) can lead to multi-organ failure or death in 10%-30% of patients. Although hyper-inflammation and immunoparalysis are well described in sepsis and are associated with high disease severity, little is known about the immune response in LD. This study aimed to evaluate the immune status of patients with LD and its association with disease severity. Methods: A total of 92 hospitalized LD patients were included; 19 plasmatic cytokines and pulmonary Results: Among the 84 patients, a higher secretion of plasmatic MCP-1, MIP1-β, IL-6, IL-8, IFN-γ, TNF-α, and IL-17 was observed in the patients with D0 and D8 MV. Multiparametric analysis showed that these seven cytokines were positively associated with the SOFA score. Upon conA stimulation, LD patients had a lower secretion capacity for 16 of the 19 quantified cytokines and a higher release of IL-18 and MCP-1 compared to HV. IL-18 secretion was higher in D0 and D8 MV patients. TNF-α secretion, measured after Discussion: The present findings describe a hyper-inflammatory phase at the initial phase of
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