Evidence map›Paper›PMID 37965217›Full record

ArticleFrontiers in neuroscience2023

The autism spectrum disorder risk gene

Rebecca A Mount, Mohamed Athif, Margaret O'Connor, Amith Saligrama, Hua-An Tseng, Sudiksha Sridhar, Chengqian Zhou, Emma Bortz, Erynne San Antonio, Mark A Kramer and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Life (Basel, Switzerland) · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Rebecca A Mount *Department of Biomedical Engineering, Boston University, Boston, MA, United States.
Mohamed Athif *Department of Biomedical Engineering, Boston University, Boston, MA, United States.
Margaret O'ConnorDepartment of Biology, Boston University, Boston, MA, United States.
Amith SaligramaDepartment of Biomedical Engineering, Boston University, Boston, MA, United States.
Hua-An TsengDepartment of Biomedical Engineering, Boston University, Boston, MA, United States.
Sudiksha SridharDepartment of Biomedical Engineering, Boston University, Boston, MA, United States.
Chengqian ZhouDepartment of Biomedical Engineering, Boston University, Boston, MA, United States.
Emma BortzDepartment of Biomedical Engineering, Boston University, Boston, MA, United States.
Erynne San AntonioDepartment of Biomedical Engineering, Boston University, Boston, MA, United States.
Mark A KramerDepartment of Mathematics, Boston University, Boston, MA, United States.
Heng-Ye ManDepartment of Biology, Boston University, Boston, MA, United States.
Xue HanDepartment of Biomedical Engineering, Boston University, Boston, MA, United States.
Boston University · US

Funding

TRAINING PROGRAM IN QUANTITATIVE BIOLOGY AND PHYSIOLOGYT32GM008764 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI WHITE, JOHN A. · 2001 to 2021
$5.9M
Translational Research in BiomaterialsT32EB006359 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MARK W. GRINSTAFF, Michelle H Teplensky · 2009 to 2026
$4.2M
Molecular mechanisms of homeostatic synaptic plasticityR01MH130600 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Hengye Man · 2023 to 2026
$1.9M
Study of NEXMIF mosaic expression on neuronal development and connectivity in female miceR21MH133014 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MAN, HENGYE · 2023 to 2024
$454k
Advanced laser scanning confocal microscope for multiple usersS10OD024993 · OD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MERTZ, JEROME · 2018 to 2018
$448k
Mechanistic study of the role of autism spectrum disorder risk genes in hippocampal CA1 population dynamics during learning and memoryF31MH123008 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MOUNT, REBECCA · 2021 to 2023
$86k
NIBIB NIH HHS T32 EB006359NIGMS NIH HHS T32 GM008764NIH HHS S10 OD024993NIMH NIH HHS F31 MH123008NIMH NIH HHS R01 MH130600NIMH NIH HHS R21 MH133014
6 · The paper itself

Abstract

Mutations in autism spectrum disorder (ASD) risk genes disrupt neural network dynamics that ultimately lead to abnormal behavior. To understand how ASD-risk genes influence neural circuit computation during behavior, we analyzed the hippocampal network by performing large-scale cellular calcium imaging from hundreds of individual CA1 neurons simultaneously in transgenic mice with total knockout of the X-linked ASD-risk gene

Indexed as

autism spectrum disorderE/I balancefunctional connectivityGCaMP6fnetwork analysisnetwork closeness centralitypairwise correlation

Identifiers

PMID37965217
PMCPMC10641898
OpenAlexW4387998418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.