Evidence map›Paper›PMID 37965143›Full record

ArticleiScience2023

TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models.

Sara L Dominguez, Benjamin I Laufer, Arundhati Sengupta Ghosh, Qingling Li, Gaia Ruggeri, Maheswara Reddy Emani, Lilian Phu, Brad A Friedman, Wendy Sandoval, Christopher M Rose and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 3 institutions in 3 countries.

Sara L DominguezDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Benjamin I LauferDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Arundhati Sengupta GhoshDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Qingling LiDepartment of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA 94080, USA.
Gaia RuggeriDepartment of Biochemistry and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA.
Maheswara Reddy EmaniDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Lilian PhuDepartment of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA 94080, USA.
Brad A FriedmanDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Wendy SandovalDepartment of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA 94080, USA.
Christopher M RoseDepartment of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA 94080, USA.
Hai NguDepartment of Pathology, Genentech, South San Francisco, CA 94080, USA.
Oded ForemanDepartment of Pathology, Genentech, South San Francisco, CA 94080, USA.
Mike ReicheltDepartment of Pathology, Genentech, South San Francisco, CA 94080, USA.
Yves JusteDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Guita LalehzadehDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Dennis HansenRoche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark.
Helle NymarkRoche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark.
Denia MellalRoche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark.
Helene GyllingRoche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark.
Łukasz J KiełpińskiRoche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark.
Ben ChihDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Baris BingolDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Casper C HoogenraadDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
William J MeilandtDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Amy EastonDepartment of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Roche (Denmark) · DKAbterra Biosciences (United States) · USGene Therapy Laboratory · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterozygous mutations in the granulin (

Indexed as

Cellular neuroscienceMolecular medicineNeuroscience

Identifiers

PMID37965143
PMCPMC10641752
OpenAlexW4388006566

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.