Evidence map›Paper›PMID 37964490›Full record

ArticleJournal of diabetes2024

The potential blunting effect of metformin and/or statin therapy on physical activity-induced associations with HbA1c in type 2 diabetes.

Joseph Henson, Melanie J Davies, Emer M Brady, Charlotte L Edwardson, Andrew P Hall, Kamlesh Khunti, Emma Redman, Alex V Rowlands, Jack Sargeant, Thomas Yates

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Joseph HensonNIHR, Leicester Biomedical Research Centre, Leicester, UK.ORCID https://orcid.org/0000-0002-3898-7053
Melanie J DaviesNIHR, Leicester Biomedical Research Centre, Leicester, UK.
Emer M BradyDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Charlotte L EdwardsonNIHR, Leicester Biomedical Research Centre, Leicester, UK.
Andrew P HallHanning Sleep Laboratory, Leicester General Hospital, Leicester, UK.
Kamlesh KhuntiDiabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK.
Emma RedmanLeicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester, UK.
Alex V RowlandsNIHR, Leicester Biomedical Research Centre, Leicester, UK.
Jack SargeantNIHR, Leicester Biomedical Research Centre, Leicester, UK.
Thomas YatesNIHR, Leicester Biomedical Research Centre, Leicester, UK.
University of Leicester · GBLeicester General Hospital · GBUniversity Hospitals of Leicester NHS Trust · GB

Funding

National Institute for Health and Care Research, Leicester Biomedical Research Centre
6 · The paper itself

Abstract

Highlights Our analysis indicates a potential blunting effect of metformin and/or statin therapy on physical activity-induced associations with HbA1c. The benefit of daily physical activity on glycemic control in people with type 2 diabetes is potentially more apparent in those prescribed neither metformin nor statin therapy. As physical activity is rarely prescribed in isolation of other background medications used to manage type 2 diabetes, the results of this analysis may help to maximize interventions delivered through routine clinical care, while allowing for personalization in prescribed physical activity and pharmacotherapy.

Indexed as

Diabetes Mellitus, Type 2Hydroxymethylglutaryl-CoA Reductase InhibitorsMetforminGlycated HemoglobinHumansHypoglycemic AgentsGlycated HemoglobinHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic AgentsMetforminmetforminphysical activitystatinstype 2 diabetes

Identifiers

PMID37964490
PMCPMC10859307
OpenAlexW4388699347

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.