Evidence map›Paper›PMID 37964407›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Oncogenic KRAS, Mucin 4, and Activin A-Mediated Fibroblast Activation Cooperate for PanIN Initiation.

Chun-Mei Hu, Chien-Chang Huang, Min-Fen Hsu, Hung-Jen Chien, Pei-Jung Wu, Yi-Ing Chen, Yung-Ming Jeng, Shiue-Cheng Tang, Mei-Hsin Chung, Chia-Ning Shen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Chun-Mei HuGenomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.ORCID 0000-0002-4248-0896
Chien-Chang HuangGenomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.
Min-Fen HsuGenomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.
Hung-Jen ChienGenomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.
Pei-Jung WuGenomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.
Yi-Ing ChenGenomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.
Yung-Ming JengDepartment of Pathology, National Taiwan University Hospital, Taipei, 10041, Taiwan.
Shiue-Cheng TangDepartment of Medical Science, National Tsing Hua University, Hsinchu, 30013, Taiwan.
Mei-Hsin ChungDepartment of Pathology, National Taiwan University Hospital-Hsinchu Branch, Hsinchu, 30331, Taiwan.
Chia-Ning ShenGenomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.
Ming-Chu ChangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, 10041, Taiwan.
Yu-Ting ChangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, 10041, Taiwan.
Yu-Wen TienDepartment of Surgery, National Taiwan University Hospital, Taipei, 10041, Taiwan.
Wen-Hwa LeeGenomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.ORCID 0000-0002-3117-931X
Genomics Research Center, Academia Sinica · TWNational Taiwan University Hospital · TWChina Medical University · TWNational Taiwan University · TWNational Tsing Hua University · TW

Funding

Academia Sinica AS-GC-110-MD03Academia Sinica AS-KPQ-111-KNTAcademia Sinica AS-SUMMIT-109Ministry of Science and Technology, Taiwan 110-2326-B-001-012
6 · The paper itself

Abstract

Over 90% of patients with pancreatic ductal adenocarcinoma (PDAC) have oncogenic KRAS mutations. Nevertheless, mutated KRAS alone is insufficient to initiate pancreatic intraepithelial neoplasia (PanIN), the precursor of PDAC. The identities of the other factors/events required to drive PanIN formation remain elusive. Here, optic-clear 3D histology is used to analyze entire pancreases of 2-week-old Pdx1-Cre; LSL-Kras

Indexed as

Carcinoma in SituCarcinoma, Pancreatic DuctalPancreatic NeoplasmsActivinsAnimalsHumansMiceMice, TransgenicMucin-4Proto-Oncogene Proteins p21(ras)activin AActivinsKRAS protein, humanMucin-4Proto-Oncogene Proteins p21(ras)activin AKrasMuc4PanINαSMA+ fibroblast

Identifiers

PMID37964407
PMCPMC10754145
OpenAlexW4388691376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.