ArticleMovement disorders : official journal of the Movement Disorder Society2023
Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.
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16 citing papers in PubMed, 27 citations in OpenAlex.
- Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life.Nature neuroscience · 2026Article
- Cerebellar Network Compensation in Parkinson's Disease: Functional Connectivity Across Motor and Cognitive Circuits.medRxiv : the preprint server for health sciences · 2026Article
- Volumetric signatures of basal ganglia-thalamo-cortical and cerebello-thalamo-cortical networks in Parkinson's disease and its motor subtypes.Frontiers in aging neuroscience · 2026Article
- Regional homogeneity differences in resting-state fMRI between Parkinson's disease and multiple system atrophy-parkinsonian type.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Contribution of Cerebellar Glutamatergic and GABAergic Systems in Premotor and Early Stages of Parkinson's Disease.International journal of molecular sciences · 2025Article
- Machine learning-based stratification of mild cognitive impairment in Parkinson's disease: a multicenter cross-sectional analysis.BMC medical informatics and decision making · 2025Article
- Cerebellar and extra-cerebellar symptoms in movement disorders.Arquivos de neuro-psiquiatria · 2025Review
- Regional-specific structural and functional changes of posterior cerebellar vermis across different stages of Parkinson's disease with gait dysfunction.NPJ Parkinson's disease · 2025Article
- Patterns of cerebellar cortex hypermetabolism on motor and cognitive functions in PD.NPJ Parkinson's disease · 2025Article
- Radiomics-based Modelling Unveils Cerebellar Involvement in Parkinson's Disease.Cerebellum (London, England) · 2025Article
- Changes in Action Tremor in Parkinson's Disease over Time: Clinical and Neuroimaging Correlates.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Review
- Integration of estimated regional gene expression with neuroimaging and clinical phenotypes at biobank scale.PLoS biology · 2024Article
- Investigation of total cerebellar and flocculonodular lobe volume in Parkinson's disease and healthy individuals: a brain segmentation study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions.Nature communications · 2024Review
- Characterization of cortical volume and whole-brain functional connectivity in Parkinson's disease patients: a MRI study combined with physiological aging brain changes.Frontiers in neuroscience · 2024Article
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Authors and funding
62 authors at 20 institutions in 13 countries.
Rebecca KerestesDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-1298-9904
Max A LaansmaDepartment Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-8216-6690
Conor Owens-WaltonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Andrew PerryMonash Bioinformatics Platform, Monash University, Melbourne, Victoria, Australia.
Eva M van HeeseDepartment Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Sarah Al-BachariFaculty of Health and Medicine, The University of Lancaster, Lancaster, United Kingdom.
Tim J AndersonNew Zealand Brain Research Institute, Christchurch, New Zealand.
Francesca AssognaLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Ítalo K AventuratoDepartment of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.
Tim D van BalkomDepartment Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-6643-2776
Henk W BerendseDepartment Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Kevin R E van den BergDepartment of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Rebecca BettsSchool of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Manchester, United Kingdom.
Ricardo BrioschiDepartment of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.
Jonathan CarrDivision of Neurology, Tygerberg Hospital and Stellenbosch University, Cape Town, South Africa.
Fernando CendesDepartment of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.ORCID 0000-0001-9336-9568
Lyles R ClarkDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
John C Dalrymple-AlfordNew Zealand Brain Research Institute, Christchurch, New Zealand.
Michiel F DirkxDepartment of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Jason DruzgalDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Helena DurrantSchool of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Manchester, United Kingdom.
Hedley C A EmsleyLancaster Medical School, Lancaster University, Lancaster, United Kingdom.
Gaëtan GarrauxGIGA-CRC in vivo imaging, University of Liège, Liège, Belgium.
Hamied A HaroonDivision of Psychology, Communication and Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Rick C HelmichDepartment of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID 0000-0003-4035-6573
Odile A van den HeuvelDepartment Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Rafael B JoãoDepartment of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.
Martin E JohanssonDepartment of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Samson G KhachatryanDepartment of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia.
Christine LochnerDepartment of Psychiatry, SA MRC Unit on Risk and Resilience in Mental Disorders, Stellenbosch University, Cape Town, South Africa.
Corey T McMillanDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Tracy R MelzerNew Zealand Brain Research Institute, Christchurch, New Zealand.ORCID 0000-0003-0621-212X
Philip E MosleyClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Benjamin NewmanDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.
Peter OpriessnigDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.
Laura M ParkesDivision of Psychology, Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0001-6488-507X
Clelia PellicanoLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Fabrizio PirasLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Toni L PitcherNew Zealand Brain Research Institute, Christchurch, New Zealand.ORCID 0000-0003-4661-5038
Kathleen L PostonDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.ORCID 0000-0003-3424-7143
Mario RangoExcellence Center for Advanced MR Techniques and Parkinson's Disease Center, Neurology unit, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital, University of Milan, Milan, Italy.
Annerine RoosDepartment of Psychiatry and Neuroscience Institute, SA MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.
Christian RummelSupport Center for Advanced Neuroimaging, (SCAN) University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Reinhold SchmidtDepartment of Neurology, Medical University of Graz, Graz, Austria.
Petra SchwingenschuhDepartment of Neurology, Medical University of Graz, Graz, Austria.
Lucas S SilvaDepartment of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.
Viktorija SmithDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Letizia SquarcinaDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Dan J SteinDepartment of Psychiatry and Neuroscience Institute, SA MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.
Zaruhi TavadyanDepartment of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia.
Chih-Chien TsaiHealthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan.
Daniela VecchioLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Chris VriendDepartment Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Jiun-Jie WangHealthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan.ORCID 0000-0002-2422-9059
Roland WiestSupport Center for Advanced Neuroimaging, (SCAN) University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Clarissa L YasudaDepartment of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.
Christina B YoungDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Ysbrand D van der WerfDepartment Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Ian H HardingDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-6843-9592
ENIGMA-Parkinson's Study
Amsterdam Neuroscience · NLUniversidade Estadual de Campinas (UNICAMP) · BRFondazione Santa Lucia · ITRadboud University Nijmegen · NLManchester Academic Health Science Centre · GBMedical University of Graz · ATSouth African Medical Research Council · ZAStanford University · USUniversity of Southern California · USMonash University · AUNational Institute of Health · AMUniversity of Bern · CHUniversity of Canterbury · NZUniversity of Manchester · GBUniversity of Milan · ITUniversity of Pennsylvania · USUniversity of Virginia · USAmsterdam University Medical Centers · NLCanterbury Health Laboratories · NZChang Gung University · TW
Funding
Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8MProject IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9MUncovering new genes and disease modifiers for ALS and related disordersU54NS092091 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Michael Benatar · 2014 to 2026
$19.8MUnderstanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Lauren M Massimo · 2020 to 2026
$18.8MUdall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3MProject IV "Tackling Heterogeneity of Cognitive Trajectory in LBD"U19AG062418 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GROSSMAN, MURRAY · 2019 to 2023
$18.1MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MIBIC: Integrated Brain Imaging Center for the University of WashingtonRC4NS073008 · NINDS · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 2010 to 2010
$4.8MNEUROBEHAVIOR, NEUROENDOCRINOLOGY, AND GENETICS OF ADT32AG000258 · NIA · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 1999 to 2013
$4.7MThe impact of early Tau pathology on cognitive progression and neuropsychiatric symptoms in Parkinson's diseaseR01NS115114 · NINDS · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I., POSTON, KATHLEEN LOMBARD · 2019 to 2023
$4.2MBiological Aging Contributions to Molecular Pathology and NeurodegenerationR01AG066152 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MCMILLAN, COREY T · 2019 to 2023
$3.8MNIA NIH HHS P01 AG066597NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG058854NIA NIH HHS R01 AG059874NIA NIH HHS R01 AG066152NIA NIH HHS R01 AG070885NIA NIH HHS R01 AG076832NIA NIH HHS R01 AG080734NIA NIH HHS R56 AG058854NIA NIH HHS T32 AG000258NIA NIH HHS U19 AG062418NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIH HHS 2019NF4100087335NIH HHS P01AG066597NIH HHS P30AG072979NIH HHS P50 NS062684NIH HHS R01AG058854NIH HHS R01AG059874NIH HHS R01AG066152NIH HHS R01 AG070885NIH HHS R01AG080734NIH HHS R01MH116147NIH HHS R01MH117601NIH HHS R01NS107513NIH HHS R01NS109260NIH HHS RC4 NS073008NIH HHS U01NS107027NIH HHS U19AG062418NIH HHS U54EB020403NIH HHS U54NS092091NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH129832NINDS NIH HHS AG062418 (U19)NINDS NIH HHS K23 NS075097NINDS NIH HHS NS053488 (P50)NINDS NIH HHS NS075097NINDS NIH HHS NS115114NINDS NIH HHS P50 NS053488NINDS NIH HHS P50 NS062684NINDS NIH HHS R01 NS107513NINDS NIH HHS R01 NS109260NINDS NIH HHS R01 NS115114NINDS NIH HHS RC4 NS073008NINDS NIH HHS U01 NS107027NINDS NIH HHS U54 NS092091Swiss National Science Foundation 180365Swiss National Science Foundation 204593 ("ScanOMetrics")
Abstract
backgroundIncreasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated.
objectiveTo quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group.
methodsCerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated.
resultsOverall, people with PD had a regionally smaller posterior lobe (d
conclusionsWe provide evidence of a dissociation between anterior "motor" lobe and posterior "non-motor" lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Indexed as
Parkinson DiseaseBrainCerebellumCross-Sectional StudiesHumansMagnetic Resonance Imagingcerebellumdisease stagingMRIParkinson's disease
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