Evidence map›Paper›PMID 37964300›Full record

Observational studyBMC psychiatry2023

An explorative single-arm clinical study to assess craving in patients with alcohol use disorder using Virtual Reality exposure (CRAVE)-study protocol.

A Lütt, N Tsamitros, T Wolbers, A Rosenthal, A L Bröcker, R Schöneck, F Bermpohl, A Heinz, A Beck, S Gutwinski

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05861843 (Craving Assessment in Patients With Alcohol Use Disorder Using Virtual Reality Exposure), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05861843 completednot on this map

Craving Assessment in Patients With Alcohol Use Disorder Using Virtual Reality Exposure

TypeobservationalSponsorCharite University, Berlin, GermanyRan2023 to 2024Enrolled61ConditionsAlcohol Use DisorderArmsVirtual Reality-based cue exposure paradigm
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

A LüttPsychiatric University Hospital Charité at St. Hedwig Hospital, 10115, Berlin, Germany. alva.luett@charite.de.
N TsamitrosPsychiatric University Hospital Charité at St. Hedwig Hospital, 10115, Berlin, Germany.
T WolbersGerman Center for Neurodegenerative Diseases (DZNE), 39120, Magdeburg, Germany.
A RosenthalDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Campus Charité Mitte, 10117, Berlin, Germany.
A L BröckerDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Campus Charité Mitte, 10117, Berlin, Germany.
R SchöneckSalus Clinic Lindow, 16835, Lindow, Germany.
F BermpohlPsychiatric University Hospital Charité at St. Hedwig Hospital, 10115, Berlin, Germany.
A HeinzPsychiatric University Hospital Charité at St. Hedwig Hospital, 10115, Berlin, Germany.
A Beck *Faculty of Health, Health and Medical University, 14471, Potsdam, Germany.
S Gutwinski *Psychiatric University Hospital Charité at St. Hedwig Hospital, 10115, Berlin, Germany.

Funding

Deutsche Forschungsgemeinschaft Project-ID 402170461 - TRR 265
6 · The paper itself

Abstract

backgroundAlcohol use disorder (AUD) belongs to the most burdensome clinical disorders worldwide. Current treatment approaches yield unsatisfactory long-term effects with relapse rates up to 85%. Craving for alcohol is a major predictor for relapse and can be intentionally induced via cue exposure in real life as well as in Virtual Reality (VR). The induction and habituation of craving via conditioned cues as well as extinction learning is used in Cue Exposure Therapy (CET), a long-known but rarely used strategy in Cognitive Behavioral Therapy (CBT) of AUD. VR scenarios with alcohol related cues offer several advantages over real life scenarios and are within the focus of current efforts to develop new treatment options. As a first step, we aim to analyze if the VR scenarios elicit a transient change in craving levels and if this is measurable via subjective and psychophysiological parameters.

methodsA single-arm clinical study will be conducted including n = 60 patients with AUD. Data on severity of AUD and craving, comorbidities, demographics, side effects and the feeling of presence in VR will be assessed. Patients will use a head-mounted display (HMD) to immerse themselves into three different scenarios (neutral vs. two target situations: a living room and a bar) while heart rate, heart rate variability, pupillometry and electrodermal activity will be measured continuously. Subjective craving levels will be assessed before, during and after the VR session. DISCUSSION: Results of this study will yield insight into the induction of alcohol craving in VR cue exposure paradigms and its measurement via subjective and psychophysiological parameters. This might be an important step in the development of innovative therapeutic approaches in the treatment of patients with AUD.

trial registrationThis study was approved by the Charité-Universitätsmedizin Berlin Institutional Review Board (EA1/190/22, 23.05.2023). It was registered on ClinicalTrials.gov (NCT05861843).

Indexed as

AlcoholismVirtual RealityAlcohol DrinkingCravingCuesHumansRecurrenceAlcohol Use DisorderCravingCue Exposure TherapyElectrodermal activityHeart rate variabilityPsychophysiological parametersPupillometryVirtual Reality

Identifiers

PMID37964300
PMCPMC10647047

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.