Evidence map›Paper›PMID 37964279›Full record

ReviewJournal of translational medicine2023

Insights into the regulatory role of RNA methylation modifications in glioma.

Shengrong Long, Yu Yan, Hongyu Xu, Lesheng Wang, Jiazhi Jiang, Ziyue Xu, Runming Liu, Qiangqiang Zhou, Xiaopeng Huang, Jincao Chen and 3 more

Abstract readReview
In one paragraph

Review in Journal of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shengrong Long *Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Yu Yan *Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Hongyu Xu *Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Lesheng WangDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Jiazhi JiangDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Ziyue XuDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Runming LiuDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Qiangqiang ZhouDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Xiaopeng HuangDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Jincao ChenDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Zhiqiang LiDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Wei WeiDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. wei.wei@whu.edu.cn.
Xiang LiDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. li.xiang@whu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epitranscriptomic abnormalities, which are highly prevalent in primary central nervous system malignancies, have been identified as crucial contributors to the development and progression of gliomas. RNA epitranscriptomic modifications, particularly the reversible modification methylation, have been observed throughout the RNA cycle. Epitranscriptomic modifications, which regulate RNA transcription and translation, have profound biological implications. These modifications are associated with the development of several cancer types. Notably, three main protein types-writers, erasers, and readers, in conjunction with other related proteins, mediate these epitranscriptomic changes. This review primarily focuses on the role of recently identified RNA methylation modifications in gliomas, such as N6-methyladenosine (m6A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), and N1-methyladenosine (m1A). We delved into their corresponding writers, erasers, readers, and related binding proteins to propose new approaches and prognostic indicators for patients with glioma.

Indexed as

GliomaTranscriptome5-MethylcytosineHumansMethylationRNA5-MethylcytosineRNAEpitranscriptomeGliomam5Cm6ARNA methylation modification

Identifiers

PMID37964279
PMCPMC10644640

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.