ArticleNature communications2023
Superior colliculus bidirectionally modulates choice activity in frontal cortex.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Somatosensory cortex shapes perceptual decision bias via the superior colliculus.Research square · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Correlates of head-fixed directional forelimb movements in mouse superior colliculus and substantia nigra pars reticulata.Neuroscience · 2026Article
- Human superior colliculus pathways represent the form and motion of looming objects.Cell reports · 2026Article
- A Distinct Circuit for Biasing Visual Perceptual Decisions and Modulating Superior Colliculus Activity through the Mouse Posterior Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Brain-wide analysis reveals movement encoding structured across and within brain areas.Nature neuroscience · 2026Article
- Cortical dopaminergic signaling mediates planning of directional movements.Science advances · 2025Article
- Superior Colliculus Projections Drive Dopamine Neuron Activity and Movement But Not Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Inpainting the Neural Picture: Inferring Unrecorded Brain Area Dynamics from Multi-Animal Datasets.ArXiv · 2025Article
- Superior colliculus projections drive dopamine neuron activity and movement but not value.bioRxiv : the preprint server for biology · 2025Article
- A distinct circuit for biasing visual perceptual decisions and modulating superior colliculus activity through the mouse posterior striatum.bioRxiv : the preprint server for biology · 2025Article
- Purkinje cells of the cerebellum control deceleration of tongue movements.PLoS biology · 2025Article
- Article
- Control of tongue movements by the Purkinje cells of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- A brainstem map of orofacial rhythms.bioRxiv : the preprint server for biology · 2025Article
- Article
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
- Article
- Behavioral measurements of motor readiness in mice.Current biology : CB · 2023Article
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10 authors.
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Abstract
Action selection occurs through competition between potential choice options. Neural correlates of choice competition are observed across frontal cortex and downstream superior colliculus (SC) during decision-making, yet how these regions interact to mediate choice competition remains unresolved. Here we report that SC can bidirectionally modulate choice competition and drive choice activity in frontal cortex. In the mouse, topographically matched regions of frontal cortex and SC formed a descending motor pathway for directional licking and a re-entrant loop via the thalamus. During decision-making, distinct neuronal populations in both frontal cortex and SC encoded opposing lick directions and exhibited competitive interactions. SC GABAergic neurons encoded ipsilateral choice and locally inhibited glutamatergic neurons that encoded contralateral choice. Activating or suppressing these cell types could bidirectionally drive choice activity in frontal cortex. These results thus identify SC as a major locus to modulate choice competition within the broader action selection network.
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