ArticleNature communications2023
Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Enteric ChAT-Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting Metabolic Pathways to Direct T-Cell Trafficking: Therapeutic Perspectives.Biomedicines · 2026Review
- Tryptophan Metabolism in Digestive and Extra-Digestive Diseases: Mechanisms, Clinical Implications, and Therapeutic Perspectives.Nutrients · 2026Review
- Localization of TCR-expressing natural intraepithelial lymphocytes in the colon epithelium depends on GPR15 and epithelium-derived C10ORF99.Mucosal immunology · 2026Article
- Ustekinumab resistance in individuals with ulcerative colitis is associated with an alteration of a subset of proinflammatory mucosal regulatory T cells.Inflammatory bowel diseases · 2026Article
- Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer.Cancer research · 2026Article
- Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota-Derived Tryptophan Metabolism and Macrophage Polarization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Serotonin, Kynurenine, and Indole Pathways of Tryptophan Metabolism in Humans in Health and Disease.Nutrients · 2026Review
- Longitudinal Evidence of Sustained Taurine Deficiency in Inflammatory Bowel Disease.International journal of molecular sciences · 2026Article
- Amino acid metabolism modulates macrophage polarization: implications for autoimmune-related diseases.Frontiers in immunology · 2026Review
- Intestinal amino acid metabolic response and its roles in inflammatory bowel disease.Cell communication and signaling : CCS · 2025Review
- C10ORF99 (GPR15L) increases susceptibility to colitis and colitis-induced colorectal cancer via GPR15-independent mechanisms, while mediating GPR15-dependent T cell migration to the large intestine.Mucosal immunology · 2025Article
- Aryl Hydrocarbon Receptor in Health and Disease.MedComm · 2025Review
- Intestinal taurine acts as a novel immunometabolic modulator of IBD by degrading redundant mitochondrial RNA.Cellular & molecular immunology · 2025Article
- Identification and validation of aryl hydrocarbon receptor-associated hub genes in ulcerative colitis via integrated bioinformatics analysis.Human genomics · 2025Article
- Targeting heat shock protein 90 with usnic acid relieves immune suppression via aryl hydrocarbon receptor-mediated mechanisms in lung cancer.Molecular biomedicine · 2025Article
- Reconstitution of T cell-mediated immunity by umbilical cord-derived mesenchymal stem cells in ulcerative colitis.Clinical and translational medicine · 2025Article
- Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch.Nature immunology · 2025Article
- Low Protein Diet Exacerbates Experimental Mouse Models of Colitis through Epithelial Autonomous and Nonautonomous Mechanisms.The Journal of nutrition · 2025Article
- Burn-Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan-Kynurenine Mediated AHR Pathway Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Nguyen T Van *Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Karen Zhang *Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Rachel M WigmoreDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-9674-5493
Anne I KennedyDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-5567-9036
Carolina R DaSilvaDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-0441-5452
Jialing HuangDepartment of Pathology, Anatomy, & Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0003-4406-7293
Manju AmbelilDepartment of Pathology, Anatomy, & Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Jose H VillagomezDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Gerald J O'ConnorDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-6728-2386
Randy S LongmanJill Roberts Center for IBD, Weill Cornell Medicine, New York, NY, USA.
Miao CaoDepartment of Pharmacology, Physiology, & Cancer Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0009-0008-7092-087X
Adam E SnookDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-9216-4560
Michael PlattenCCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-4746-887X
Gerard KasentyDepartment of Genetics and Development, Irving Medical Center, Columbia University, NY, USA.
Luis J SigalDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-6642-5472
George C PrendergastSidney Kimmel Cancer Center, Jefferson Health, Philadelphia, PA, USA.ORCID 0000-0002-1449-7332
Sangwon V KimDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. svkim@jefferson.edu.ORCID 0000-0001-8453-7080
Thomas Jefferson University · USColumbia University Irving Medical Center · USCornell University · USGeisinger Medical Center · USGerman Cancer Research Center · DELankenau Institute for Medical Research · US
Funding
X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8MLocal immune tolerance in the large intestine mediated by GPR15R01AI141787 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI KIM, SANGWON VINCENT · 2020 to 2024
$2.7MRole of novel host protein, C10orf99, in T cell homing to the large intestineR21AI142318 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI KIM, SANGWON VINCENT · 2019 to 2020
$429kNCI NIH HHS P30 CA056036NIAID NIH HHS R01 AI141787NIAID NIH HHS R21 AI142318
Abstract
Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous dietary component, determines the transcription level of the colonic T cell homing receptor, GPR15, hence affecting the number of colonic FOXP3
Indexed as
ColitisColitis, UlcerativeAnimalsColonHumansMiceReceptors, G-Protein-CoupledReceptors, PeptideT-Lymphocytes, RegulatoryTryptophanGPR15 protein, humanReceptors, G-Protein-CoupledReceptors, PeptideTryptophan
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.