ArticleNature communications2023
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Mobilizing antigen-presenting mast cells in anti-PD-1-refractory triple-negative breast cancer: a phase 2 trial.Nature medicine · 2025Trial
- Vitronectin metabolically programs profibrotic macrophages in 3D cultures and idiopathic pulmonary fibrosis.Science advances · 2026Article
- Peripheral Blood Inflammatory Markers and Immune Cell Profiles in Smokers With and Without COPD.Pulmonary therapy · 2026Article
- Short-term cigarette smoke exposure aggravates oxidative stress and airway inflammation induced by lipopolysaccharides.Frontiers in physiology · 2026Article
- Multi-omics to study chronic respiratory diseases and viral infections.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Biodegradable 3D Injectable Amino Acid Hydrogels Delivering Immune Adjuvant for Enhancing Immunotherapy in Colon Cancer.Cancer science · 2025Article
- Machine learning assisted immune profiling of COPD identifies a unique emphysema subtype independent of GOLD stage.iScience · 2025Article
- The nitrofen/bisdiamine murine model of congenital diaphragmatic hernia has a pulmonary hypertension vascular phenotype consistent with human CDH.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Article
- Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Role of toll-like receptors in pulmonary immunity: mechanisms and therapeutic implications.Frontiers in immunology · 2025Review
- TLR7 Promotes Acute Inflammatory-Driven Lung Dysfunction in Influenza-Infected Mice but Prevents Late Airway Hyperresponsiveness.International journal of molecular sciences · 2024Article
- Tobacco and COPD: presenting the World Health Organization (WHO) Tobacco Knowledge Summary.Respiratory research · 2024Review
- Review
Corrections and comments
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Authors and funding
40 authors at 16 institutions in 9 countries.
Gang Liu *Centre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-0489-2638
Tatt Jhong Haw *Immune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0003-2315-7089
Malcolm R Starkey *Depatrment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Ashleigh M PhilpCentre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia.
Stelios PavlidisThe Airways Disease Section, National Heart & Lung Institute, Imperial College London, London, UK.
Christina NalkurthiCentre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia.
Prema M NairImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.
Henry M GomezImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.
Irwan HanishImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.
Alan Cy HsuImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.
Elinor HortleCentre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia.
Sophie PicklesCentre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia.
Joselyn Rojas-QuinteroDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Raul San Jose EsteparDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Jacqueline E MarshallCentre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia.
Richard Y KimImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.
Adam M CollisonImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.ORCID 0000-0002-3074-3046
Joerg MattesImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.
Sobia IdreesCentre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia.
Alen FaizCentre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0003-1740-3538
Nicole G HansbroCentre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia.
Ryutaro FukuiDivision of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minatoku, Tokyo, Japan.
Yusuke MurakamiFaculty of Pharmacy, Department of Pharmaceutical Sciences, Musashino University, Nishitokyo-shi, Tokyo, Japan.ORCID 0000-0001-6820-709X
Hong Sheng ChengLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0001-9745-7872
Nguan Soon TanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0003-0136-7341
Sanjay H ChotirmallLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0003-0417-7607
Jay C HorvatImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.
Paul S FosterImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.
Brian Gg OliverWoolcock Institute of Medical Research, University of Sydney & School of Life Sciences, University of Technology, Sydney, Australia.
Francesca PolverinoDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Antonio IeniDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Section of Anatomic Pathology, Università di Messina, Messina, Italy.
Francesco MonacoThoracic Surgery, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy.
Gaetano CaramoriPneumologia, Dipartimento BIOMORF and Dipartimento di Medicina e Chirurgia, Universities of Messina and Parma, Messina, Italy.ORCID 0000-0002-9807-327X
Sukhwinder S SohalRespiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, University of Tasmania, Launceston, Australia.
Ken R BrackeLaboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0001-5906-4605
Peter A WarkImmune Healthy &/or Grow Up Well, Hunter Medical Research Institute & University of Newcastle, Callaghan, New South Wales, Australia.
Ian M AdcockSchool of Clinical Medicine, UNSW Medicine and Health, St Vincent's Healthcare clinical campus, UNSW, Sydney, Australia.ORCID 0000-0003-2101-8843
Kensuke MiyakeDivision of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minatoku, Tokyo, Japan.
Don D SinThe University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital & Respiratory Division, Dept of Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-0756-6643
Philip M HansbroCentre for Inflammation, Centenary Institute, and Faculty of Science, University of Technology Sydney, Camperdown, New South Wales, Australia. philip.hansbro@uts.edu.au.ORCID 0000-0002-4741-3035
University of Technology Sydney · AUHunter Medical Research Institute · AUNanyang Technological University · SGBaylor College of Medicine · USThe University of Tokyo · JPUniversity of Messina · ITBrigham and Women's Hospital · USGhent University Hospital · BEImperial College London · GBIstituto Ortopedico Gaetano Pini · ITMonash University · AUMusashino University · JPUniversiti Putra Malaysia · MYUniversity of British Columbia · CAUniversity of Tasmania · AUUNSW Sydney · AU
Funding
Department of Health | National Health and Medical Research Council (NHMRC) 1023131Department of Health | National Health and Medical Research Council (NHMRC) 1137995
Abstract
Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that the severity of CS-induced emphysema and COPD is reduced in TLR7-deficient mice, while inhalation of imiquimod, a TLR7-agonist, induces emphysema without CS exposure. This imiquimod-induced emphysema is reduced in mice deficient in mast cell protease-6, or when wild-type mice are treated with the mast cell stabilizer, cromolyn. Furthermore, therapeutic treatment with anti-TLR7 monoclonal antibody suppresses CS-induced emphysema, experimental COPD and accumulation of pulmonary mast cells in mice. Lastly, TLR7 mRNA is increased in pre-existing datasets from patients with COPD, while TLR7
Indexed as
EmphysemaPulmonary Disease, Chronic ObstructivePulmonary EmphysemaAnimalsHumansImiquimodLungMiceMice, Inbred C57BLNicotianaToll-Like Receptor 7TryptasesImiquimodTLR7 protein, humanToll-Like Receptor 7Tryptases
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.