Evidence map›Paper›PMID 37963819›Full record

ArticleProteomics2024

Eye proteome of Drosophila melanogaster.

Mukesh Kumar, Canan Has, Khanh Lam-Kamath, Sophie Ayciriex, Deepshe Dewett, Mhamed Bashir, Clara Poupault, Kai Schuhmann, Henrik Thomas, Oskar Knittelfelder and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Light-induced remodeling of theScience signaling · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Mukesh KumarMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Canan HasMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Khanh Lam-KamathDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, Boston, Massachusetts, USA.
Sophie AyciriexMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0003-4813-5900
Deepshe DewettDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, Boston, Massachusetts, USA.
Mhamed BashirDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, Boston, Massachusetts, USA.
Clara PoupaultDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, Boston, Massachusetts, USA.
Kai SchuhmannMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Henrik ThomasMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Oskar KnittelfelderMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Bharath Kumar RaghuramanMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Robert AhrendsDepartment of Analytical Chemistry, University of Vienna, Vienna, Austria.
Jens RisterDepartment of Biology, University of Massachusetts Boston, Integrated Sciences Complex, Boston, Massachusetts, USA.
Andrej ShevchenkoMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0002-5079-1109

Funding

Mechanisms of vitamin A deprivation and replacement therapyR01EY029659 · NEI · UNIVERSITY OF MASSACHUSETTS BOSTON · PI RISTER, JENS · 2019 to 2023
$1.9M
National Eye Institute of the National Institutes of HealthNEI NIH HHS R01 EY029659
6 · The paper itself

Abstract

Drosophila melanogaster is a popular model organism to elucidate the molecular mechanisms that underlie the structure and function of the eye as well as the causes of retinopathies, aging, light-induced damage, or dietary deficiencies. Large-scale screens have isolated genes whose mutation causes morphological and functional ocular defects, which led to the discovery of key components of the phototransduction cascade. However, the proteome of the Drosophila eye is poorly characterized. Here, we used GeLC-MS/MS to quantify 3516 proteins, including the absolute (molar) quantities of 43 proteins in the eye of adult male Drosophila reared on standard laboratory food. This work provides a generic and expandable resource for further genetic, pharmacological, and dietary studies.

Indexed as

Drosophila melanogasterDrosophila ProteinsProteomeTandem Mass SpectrometryAnimalsEyeEye ProteinsMaleProteomicsDrosophila ProteinsEye ProteinsProteomeabsolute quantificationDrosophila melanogastereye proteomephototransduction

Identifiers

PMID37963819
PMCPMC11258641

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.