ArticleJournal of neurology, neurosurgery, and psychiatry2024
Unravelling the influence of affective stimulation on functional neurological symptoms: a pilot experiment examining potential mechanisms.
Article in Journal of neurology, neurosurgery, and psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Measurement Properties of the Patient Health Questionnaire-15 and Somatic Symptom Scale-8: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Investigating mechanisms and monitoring outcomes in functional neurological disorder: the unrealized potential of digital remote monitoring technologies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Somatic yoga therapy for functional neurological disorder: feasibility randomised controlled trial.BJPsych open · 2026Article
- Momentary predictors of dissociation in functional neurological disorder: an ecological momentary assessment-based pilot study.Frontiers in psychiatry · 2026Article
- Locus coeruleus co-activation patterns at rest show higher state persistence in patients with dissociative seizures: A Pilot Study.Epilepsia open · 2024Article
- Real-time biopsychosocial antecedents and correlates of functional neurological symptoms in daily life: A pilot remote monitoring technology study.Psychiatry research · 2024Article
- Investigating psychobiological causes and mechanisms in functional seizures and functional motor symptoms: Study protocol.PloS one · 2024Article
- Functional neurological disorder, physical activity and exercise: What we know and what we can learn from comorbid disorders.Epilepsy & behavior reports · 2024Review
- Heartbeat evoked potentials and autonomic arousal during dissociative seizures: insights from electrophysiology and neuroimaging.BMJ neurology open · 2024Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDifferences in affective processing have previously been shown in functional neurological disorder (FND); however, the mechanistic relevance is uncertain. We tested the hypotheses that highly arousing affective stimulation would result in elevated subjective functional neurological symptoms (FNS), and this would be associated with elevated autonomic reactivity. The possible influence of cognitive detachment was also explored.
methodIndividuals diagnosed with FND (motor symptoms/seizures; n=14) and healthy controls (n=14) viewed Positive, Negative and Neutral images in blocks, while passively observing the stimuli ('Watch') or detaching themselves ('Distance'). The FND group rated their primary FNS, and all participants rated subjective physical (arousal, pain, fatigue) and psychological states (positive/negative affect, dissociation), immediately after each block. Skin conductance (SC) and heart rate (HR) were monitored continuously.
resultsFNS ratings were higher after Negative compared with Positive and Neutral blocks in the FND group (p=0.002, η
conclusionsEmotionally significant events may exert an influence on FNS which is related to autonomic activation rather than altered subjective affect or perceived arousal. This influence may be modulated by cognitive detachment. Further work is needed to determine the relevance and neural bases of these processes in specific FND phenotypes.
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