Evidence map›Paper›PMID 37963664›Full record

ArticleBMJ case reports2023

Rare case of central congenital hypothyroidism due to a

Madhura Bharat Karguppikar, Nadia Schoenmakers, Vaman Khadilkar, Anuradha Khadilkar

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Madhura Bharat KarguppikarPaediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, India.
Nadia SchoenmakersWellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge Metabolic Research Laboratories, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Vaman KhadilkarGrowth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Pune, India.
Anuradha KhadilkarHirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, India anuradhavkhadilkar@gmail.com.ORCID http://orcid.org/0000-0001-9832-7033
Jehangir Hospital · INUniversity of Cambridge · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

A male infant was brought to our paediatric endocrine unit with typical clinical features of congenital hypothyroidism (CH) and striking macro-orchidism. On evaluation, free T3, free T4 and thyroid stimulating hormone (TSH) were found to be low, suggestive of congenital CH. Cortisol was within reference range and prolactin was mildly elevated. No suspicious lesions were encountered on neurosonography. On commencing treatment with thyroxine, clinical features of hypothyroidism showed dramatic improvement with regression of testicular enlargement. Genetic analysis revealed deletion of the

Indexed as

Congenital HypothyroidismChildHumansInfantMaleMutationThyroid Function TestsThyrotropinThyroxineThyrotropinThyroxineendocrine systempaediatrics (drugs and medicines)thyroid disease

Identifiers

PMID37963664
PMCPMC10649689
OpenAlexW4388653211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.