ArticleThoracic cancer2023
Clinical definition of secondary resistance to immunotherapy in non-small cell lung cancer.
Open access · goldAbstract read
In one paragraph
Article in Thoracic cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Multi-omics integration in deciphering non-small cell lung cancer drug resistance: current status, challenges, and future prospects.Hereditas · 2026Review
- Perioperative Immunotherapy for Non-Small Cell Lung Cancer (NSCLC).Current oncology reports · 2025Review
- Anti-Resistant Strategies: Icotinib Derivatives as Promising Non-Small Cell Lung Cancer Therapeutics.Current cancer drug targets · 2025Article
- Clinical definition of secondary resistance to immunotherapy in non-small cell lung cancer.Thoracic cancer · 2023Article
Corrections and comments
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Authors and funding
106 authors at 20 institutions in 3 countries.
Dingzhi HuangDepartment of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.ORCID 0000-0002-2798-9459
Gen LinDepartment of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.ORCID 0000-0001-6793-552X
Qian ChuDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Yi HuSenior Department of Oncology, Chinese PLA General Hospital, Beijing, People's Republic of China.ORCID 0000-0001-9319-5692
Jun WangDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, People's Republic of China.ORCID 0000-0003-3941-2507
Zhijie WangDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Fan YangDepartment of Thoracic Surgery, Peking University People Hospital, Beijing, People's Republic of China.
Wenzhao ZhongGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.ORCID 0000-0002-8917-8635
Chengzhi ZhouPulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.ORCID 0000-0003-0029-6879
Bo ZhuInstitute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, People's Republic of China.
Xinghao AiShanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Baoshan CaoCancer center, Peking University Third Hospital/ Department of medical oncology and radiation sickness, Peking University Third Hospital, Beijing, People's Republic of China.
Yabing CaoDepartment of oncology, Kiang Wu Hospital, Macau, People's Republic of China.
Mingqiu ChenDepartment of Thoracic Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Xiaohui ChenDepartment of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Tianqing ChuRespiratory Department, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Jianchun DuanDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.ORCID 0000-0003-1479-2304
Yun FanDepartment of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Yong FangDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhenjiang University School of Medicine, Hangzhou, People's Republic of China.
Shuitu FengDepartment of Medical Oncology, Fudan University Shanghai Cancer Center Xiamen Hospital, Xiamen, People's Republic of China.
Weineng FengDepartment of Pulmonary Oncology, The First People's Hospital of Foshan, Foshan, People's Republic of China.
Hui GuoDepartment of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Chengbo HanDepartment of Oncology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.ORCID 0000-0001-8391-6134
Yong HeDepartment of Respiratory Medicine, Xinqiao Hospital, Army Medical University, Chongqing, People's Republic of China.ORCID 0000-0002-9404-798X
Shaodong HongState Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Jie HuZhongshan Hospital, Fudan University, Shanghai Geriatric Center, Shanghai, People's Republic of China.
Meijuan HuangDivision of Thoracic Tumor Multimodality Treatment and Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.ORCID 0000-0002-3390-9697
Yan HuangState Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Da JiangDepartment of Oncology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Kan JiangDepartment of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Richeng JiangDepartment of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Bo JinDepartment of Medical Oncology, The First affiliated hospital of China Medical University, Shenyang, People's Republic of China.
Shi JinNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital &Shenzhen Hospital, Chinese Academy of Medical Sciences and Perking Union Medical College, Shenzhen, People's Republic of China.ORCID 0000-0002-4462-2931
Jisheng LiDepartment of Medical Oncology, Qilu Hospital of Shandong University, Ji'nan, People's Republic of China.ORCID 0000-0002-4186-6228
Min LiDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Ziming LiShanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Chao LiDepartment of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Jie LinDepartment of Medical Oncology, The Second Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
Anwen LiuDepartment of Medical Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Si-Yang Maggie LiuDepartment of Hematology, First Affiliated Hospital, Ji'nan University, Guangzhou, People's Republic of China.
Yutao LiuDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Zhefeng LiuSenior Department of Oncology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Zhe LiuDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing, People's Republic of China.
Zhenhua LiuDepartment of Oncology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, People's Republic of China.
Zhentian LiuDepartment of Thoracic Oncology，Jiangxi Cancer Hospital, Nanchang, People's Republic of China.
Zhigang LiuCancer Center, The 10th Affiliated Hospital of Southern Medical University, Dongguan, People's Republic of China.
Yuping LuDepartment of Abdominal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Tangfeng LvDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China.ORCID 0000-0001-7224-8468
Zhiyong MaDepartment of Respiratory Medicine, Henan Cancer Hospital /Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Qian MiaoDepartment of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Min PengCancer center, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.ORCID 0000-0001-6648-945X
Xingxiang PuDepartment of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People's Republic of China.
Xiu Bao RenDepartment of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Jianzhen ShanDepartment of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Zhejiang, People's Republic of China.
Jinlu ShanDepartment of Medical Oncology, Daping Hospital, Army Medical University, Chongqing, People's Republic of China.
Peng ShenDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
Bo ShenDepartment of Medical Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People's Republic of China.ORCID 0000-0001-5709-5213
Meiqi ShiDepartment of Medical Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People's Republic of China.ORCID 0000-0002-3578-4082
Yong SongDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China.ORCID 0000-0003-4979-4131
Zhengbo SongDepartment of Clinical Trial, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
ChunXia SuDepartment of Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China.
Jianguo SunInstitute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, People's Republic of China.
Panwen TianDepartment of Pulmonary and Critical Care Medicine, Lung Cancer Center, West China Hospital, Sichuan University, Precision Medicine Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.ORCID 0000-0002-6313-3228
Jinliang WangSenior Department of Oncology, Chinese PLA General Hospital, Beijing, People's Republic of China.
Feng WangDepartment of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Huijuan WangDepartment of Respiratory Medicine, Henan Cancer Hospital /Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Jialei WangDepartment of Thoracic Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Qian WangDepartment of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People's Republic of China.
Wenxian WangDepartment of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.ORCID 0000-0002-3047-4149
Yan WangDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.ORCID 0000-0002-1743-6383
Lin WuDepartment of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People's Republic of China.
Fang WuDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.ORCID 0000-0002-6627-3437
Yang XiaDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.ORCID 0000-0003-2487-2244
Congying XieDepartment of Radiation and Medical Oncology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.ORCID 0000-0002-1693-9034
Conghua XieDepartment of Pulmonary Oncology, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.ORCID 0000-0001-6623-9864
Tao XinDepartment of Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Jianping XiongDepartment of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Haipeng XuDepartment of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Song XuDepartment of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.ORCID 0000-0001-6153-387X
Yiquan XuDepartment of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Bin XuCancer center, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
Chunwei XuDepartment of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China.ORCID 0000-0002-9021-6731
Xiaolong YanDepartment of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, People's Republic of China.
Zhenzhou YangDepartment of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Wenxiu YaoDepartment of Medical Oncology, Sichuan Cancer Hospital, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Yao YuDepartment of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Ye FengDepartment of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People's Republic of China.
Zongyang YuDepartment of Respiratory Medicine, The 900th Hospital of the Joint Logistic Support Force, People's Liberation Army of China, Fuzhou, People's Republic of China.
Yongfeng YuShanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Dongsheng YueDepartment of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Haibo ZhangDepartment of Oncology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, People's Republic of China.
HongMei ZhangDepartment of Clinical Oncology, Xijing Hospital, Air Force Medical University, Xi'an, People's Republic of China.
Li ZhangDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Longfeng ZhangDepartment of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Qiuyu ZhangInstitute of Immunotherapy, Fujian Medical University, Fuzhou, People's Republic of China.
Tongmei ZhangDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing, People's Republic of China.ORCID 0000-0003-4271-3773
Bicheng ZhangCancer center, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
Jun ZhaoKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department I of Thoracic Oncology, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.ORCID 0000-0003-1464-7158
Mingfang ZhaoDepartment of Medical Oncology, The First affiliated hospital of China Medical University, Shenyang, People's Republic of China.
Xiaobin ZhengDepartment of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Fengqiao ZhongDepartment of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.
Jin ZhouDepartment of Medical Oncology, Sichuan Cancer Hospital, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Penghui ZhouState Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Zhengfei ZhuDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Juntao ZouDepartment of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Zihua ZouDepartment of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.ORCID 0000-0003-0677-3998
Fujian Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNCentral South University · CNChinese PLA General Hospital · CNShanghai Jiao Tong University · CNTianjin Medical University Cancer Institute and Hospital · CNArmy Medical University · CNNanchang University · CNNanjing General Hospital of Nanjing Military Command · CNPeking University · CNSun Yat-sen University · CNWuhan University · CNZhejiang Cancer Hospital · CNFirst Hospital of China Medical University · CNFudan University Shanghai Cancer Center · CNGuangzhou University of Chinese Medicine · CNJiangsu Cancer Hospital · CNSichuan University · CNUniversity of Electronic Science and Technology of China · CNWenzhou Medical University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune checkpoint inhibitors (PD-1/PD-L1 and CTLA-4 blockade) have revolutionized the treatment landscape in non-small cell lung cancer (NSCLC). Secondary resistance to immunotherapy (IO), which poses a substantial challenge in clinical settings, occurs in several initial responders. Currently, new treatment approaches have been extensively evaluated in investigational studies for these patients to tackle this difficult problem; however, the lack of consistency in clinical definition, uniform criteria for enrollment in clinical trials, and interpretation of results remain significant hurdles to progress. Thus, our expert panel comprehensively synthesized data from current studies to propose a practical clinical definition of secondary resistance to immunotherapy in NSCLC in metastatic and neoadjuvant settings. In addition to patients who received IO alone (including IO-IO combinations), we also generated a definition for patients treated with chemotherapy plus IO. This consensus aimed to provide guidance for clinical trial design and facilitate future discussions with investigators. It should be noted that additional updates in this consensus are required when new data is available.
Indexed as
Carcinoma, Non-Small-Cell LungLung NeoplasmsB7-H1 AntigenHumansImmunotherapyNeoadjuvant TherapyB7-H1 AntigenimmunotherapyNSCLCsecondary resistance
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