Evidence map›Paper›PMID 37963248›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Histone deacetylation and cytosine methylation compartmentalize heterochromatic regions in the genome organization of

Ashley W Scadden, Alayne S Graybill, Clayton Hull-Crew, Tiffany J Lundberg, Nickolas M Lande, Andrew D Klocko

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. A Translocation within thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. HISTONE DEACETYLASE-1 is required for epigenome stability inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ashley W ScaddenDepartment of Chemistry and Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO 80918.ORCID 0000-0001-7603-1442
Alayne S GraybillDepartment of Chemistry and Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO 80918.ORCID 0009-0003-2366-1637
Clayton Hull-CrewDepartment of Chemistry and Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO 80918.ORCID 0000-0001-5984-2972
Tiffany J LundbergDepartment of Chemistry and Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO 80918.ORCID 0009-0007-2691-8054
Nickolas M LandeDepartment of Chemistry and Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO 80918.ORCID 0009-0000-4218-2277
Andrew D KlockoDepartment of Chemistry and Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO 80918.ORCID 0000-0002-2236-672X
University of Colorado Colorado Springs · US

Funding

Genome topology in the filamentous fungus Neurospora crassa: organizing factors and impact on genome functionR15GM140396 · NIGMS · UNIVERSITY OF COLORADO · PI KLOCKO, ANDREW DAVID · 2020 to 2025
$607k
NIGMS NIH HHS R15 GM140396
6 · The paper itself

Abstract

Chromosomes must correctly fold in eukaryotic nuclei for proper genome function. Eukaryotic organisms hierarchically organize their genomes, including in the fungus

Indexed as

HistonesNeurospora crassaCytosineDNADNA MethylationHeterochromatinProtein Processing, Post-TranslationalCytosineDNAHeterochromatinHistonescytosine methylationgenome organizationheterochromatinHi-Chistone deacetylation

Identifiers

PMID37963248
PMCPMC10666030
OpenAlexW4388665564

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.