Evidence map›Paper›PMID 37963067›Full record

ArticleChemical research in toxicology2023

Mass Spectrometry-Based Strategies for Assessing Human Exposure Using Hemoglobin Adductomics.

Andrew T Rajczewski, Lorena Ndreu, Efstathios Vryonidis, Alexander K Hurben, Sara Jamshidi, Timothy J Griffin, Margareta Å Törnqvist, Natalia Y Tretyakova, Isabella Karlsson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrew T RajczewskiDepartment of Biochemistry, University of Minnesota, Minneapolis, Minnesota55455, United States.ORCID 0000-0002-5119-8075
Lorena NdreuDepartment of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden.ORCID 0000-0003-1567-4262
Efstathios VryonidisDepartment of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden.
Alexander K HurbenDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota55455, United States.ORCID 0000-0002-4016-1103
Sara JamshidiDepartment of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden.
Timothy J GriffinDepartment of Biochemistry, University of Minnesota, Minneapolis, Minnesota55455, United States.ORCID 0000-0001-6801-2559
Margareta Å TörnqvistDepartment of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden.ORCID 0000-0002-5626-1125
Natalia Y TretyakovaDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota55455, United States.ORCID 0000-0002-0621-6860
Isabella KarlssonDepartment of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden.ORCID 0000-0002-5924-6123

Funding

Untargeted Adductomics to Characterize Ethnic Differences in the Exposome of SmokersP01CA138338 · NCI · UNIVERSITY OF MINNESOTA · PI STEPHEN S HECHT · 2010 to 2026
$33.4M
NCI NIH HHS P01 CA138338
6 · The paper itself

Abstract

Hemoglobin (Hb) adducts are widely used in human biomonitoring due to the high abundance of hemoglobin in human blood, its reactivity toward electrophiles, and adducted protein stability for up to 120 days. In the present paper, we compared three methods of analysis of hemoglobin adducts: mass spectrometry of derivatized N-terminal Val adducts, mass spectrometry of N-terminal adducted hemoglobin peptides, and limited proteolysis mass spectrometry . Blood from human donors was incubated with a selection of contact allergens and other electrophiles, after which hemoglobin was isolated and subjected to three analysis methods. We found that the FI

Indexed as

DinitrochlorobenzeneHemoglobinsHumansMass SpectrometryDinitrochlorobenzeneHemoglobins

Identifiers

PMID37963067
PMCPMC10731639

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.