Evidence map›Paper›PMID 37962942›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

Defining a timeline of colon pathologies after keratin 8 loss: rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation.

Maria A Ilomäki, Lauri Polari, Carl-Gustaf A Stenvall, Mina Tayyab, Kirah Kähärä, Karen M Ridge, Diana M Toivola

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Maria A IlomäkiCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Lauri PolariCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.ORCID 0000-0002-0052-6489
Carl-Gustaf A StenvallCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Mina TayyabCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Kirah KähäräCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Karen M RidgeDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States.ORCID 0000-0001-7784-0014
Diana M ToivolaCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Åbo Akademi University · FINorthwestern University · US

Funding

The Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9M
Academy of Finland (AKA) 332582Academy of Finland (AKA) 337531Agneta and Carl-Erik Olin foundationHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HLI154998K Albin Johansson foundationMedicinska Understödsföreningen Liv och Hälsa (Medicinska Understödsföreningen Liv och Hälsa r.f.)Suomen Kulttuurirahasto (SKR) 85222249Svenska Kulturfonden (Svenska Kulturfondenista)Victoriastiftelsen (Victoria Foundation)
6 · The paper itself

Abstract

Keratins are epithelial intermediate filament proteins that play a crucial role in cellular stress protection, with K8 being the most abundant in the colon. The intestinal epithelial-specific K8-deficient mouse model (K8

Indexed as

ColitisKeratin-8AnimalsDiarrheaKeratin-18KeratinsMiceKeratin-18Keratin-8KeratinsKrt8 protein, mousecolonexfoliated cellskeratinmouse modelnoninvasive

Identifiers

PMID37962942
PMCPMC11208023
OpenAlexW4388656372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.