Trial reportActa odontologica Scandinavica2024
Supra- and sub-gingival instrumentation of periodontitis with the adjunctive treatment of a chloramine - a one-year randomized clinical trial study.
Trial report in Acta odontologica Scandinavica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05757921 (Non-surgical Treatment of Periodontitis With or Without the Adjunctive Treatment of Perisolv®), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-surgical Treatment of Periodontitis With or Without the Adjunctive Treatment of Perisolv®
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Adjunctive Local Agents to Subgingival Instrumentation in the Treatment of Periodontitis: A Review of Recent Clinical Trials and Future Perspectives.Pharmaceutics · 2025Review
- Comparative efficacy of different anesthetic techniques on pain perception during nonsurgical periodontal treatment: A parallel, blinded, randomized controlled trial.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a bacterial-induced disease and for this reason controlling the microbiota is a necessity. Therapy includes self-performed daily oral hygiene in combination with supra- and sub-gingival instrumentation. An adjunctive antimicrobial agent may improve the outcome.
aimsTo assess whether a chloramine (Perisolv®) has an adjunctive effect to non-surgical periodontal therapy and whether non-surgical periodontal therapy affects quality of life. MATERIAL AND
methodsThirty-eight patients were randomized to a test or a control group. Clinical indices were performed at baseline and at three and twelve months. In the test group, Perisolv® was applied initially and after the sub-gingival instrumentation in pathological pockets. Oral health-related quality of life was measured with the Oral Health Impact Profile (OHIP) instrument at baseline and twelve months.
resultsIn both groups, an initial probing pocket depth (PPD) of > 4 mm and bleeding on probing (BOP) were statistically reduced (p < 0.002 and p < 0.002 respectively) at twelve months and after adjustment for Bonferroni. There were no significant differences between the test and the control group in terms of the number of PPD, BOP or plaque index, or in the mean OHIP score.
conclusionsChloramine did not have an adjunctive effect, but the overall therapy was significantly efficacious both clinically and in terms of quality of life.
trial registrationRegistered at www. CLINICALTRIALS: gov:NCT05757921.
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Registered trials
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