Evidence map›Paper›PMID 37962810›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2023

Low-dose IL-2 Treatment Rescues Cognitive Deficits by Repairing the Imbalance Between Treg and Th17 Cells at the Middle Alzheimer's Disease Stage.

Lin Yuan, Lei Xie, Hao Zhang, Yu Zhang, Yunbo Wei, Jinhong Feng, Li Cui, Rui Tian, Jia Feng, Di Yu and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 15 citations in OpenAlex.

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  7. The spleen-brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lin YuanHubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Hubei Minzu University, Enshi, Hubei, China.
Lei XieLaboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), #19 Keyuan Road, Lixia District, Jinan, 250014, Shandong, China.
Hao ZhangLaboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), #19 Keyuan Road, Lixia District, Jinan, 250014, Shandong, China.
Yu ZhangLaboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), #19 Keyuan Road, Lixia District, Jinan, 250014, Shandong, China.
Yunbo WeiLaboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), #19 Keyuan Road, Lixia District, Jinan, 250014, Shandong, China.
Jinhong FengLaboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), #19 Keyuan Road, Lixia District, Jinan, 250014, Shandong, China.
Li CuiLaboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), #19 Keyuan Road, Lixia District, Jinan, 250014, Shandong, China.
Rui TianHubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Hubei Minzu University, Enshi, Hubei, China.
Jia FengHubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Hubei Minzu University, Enshi, Hubei, China.
Di YuThe University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, Australia. di.yu@uq.edu.au.ORCID http://orcid.org/0000-0003-1721-8922
Cui LvLaboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), #19 Keyuan Road, Lixia District, Jinan, 250014, Shandong, China. lvc2020@qlu.edu.cn.
Qilu University of Technology · CNMinzu University of China · CNShandong University of Traditional Chinese Medicine · CNThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple studies highlight the role of effector and regulatory CD4

Indexed as

Alzheimer DiseaseCognitive DysfunctionAnimalsCognitionHumansInterleukin-2MiceTh17 CellsT-Lymphocytes, RegulatoryInterleukin-2Alzheimer’s diseaseCognitive deficitsImbalanceLow-dose IL-2 treatmentTh17Treg

Identifiers

PMID37962810
OpenAlexW4388670202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.