Evidence map›Paper›PMID 37962684›Full record

ArticleVirchows Archiv : an international journal of pathology2024

Large B-cell lymphoma with IRF4 rearrangement: a multi-centric study with focus on potential misleading phenotypes.

Marco Pizzi, Lucia Bongiovanni, Luisa Lorenzi, Simona Righi, Federico Scarmozzino, Piera Balzarini, Luisa Santoro, Lara Mussolin, Elisa Carraro, Marta Pillon and 6 more

Erratum issuedOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Marco PizziSurgical Pathology and Cytopathology Unit, Department of Medicine - DIMED, University of Padua School of Medicine, via A. Gabelli, 61, 35121, Padua, PD, Italy. marco.pizzi.1@unipd.it.ORCID http://orcid.org/0000-0003-4006-7317
Lucia BongiovanniHaematopathology Diagnostic Area, Pathology Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Luisa LorenziSection of Pathology, Department of Molecular and Translational Medicine, University of Brescia School of Medicine, Spedali Civili di Brescia, Brescia, Italy.
Simona RighiDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Federico ScarmozzinoSurgical Pathology and Cytopathology Unit, Department of Medicine - DIMED, University of Padua School of Medicine, via A. Gabelli, 61, 35121, Padua, PD, Italy.
Piera BalzariniSection of Pathology, Department of Molecular and Translational Medicine, University of Brescia School of Medicine, Spedali Civili di Brescia, Brescia, Italy.
Luisa SantoroSurgical Pathology and Cytopathology Unit, Department of Medicine - DIMED, University of Padua School of Medicine, via A. Gabelli, 61, 35121, Padua, PD, Italy.
Lara MussolinOncohematology Unit, Maternal and Child Health Department, Pediatric Hematology, Oncology and Stem Cell Transplant Center, University of Padua School of Medicine, Padua, Italy.
Elisa CarraroOncohematology Unit, Maternal and Child Health Department, Pediatric Hematology, Oncology and Stem Cell Transplant Center, University of Padua School of Medicine, Padua, Italy.
Marta PillonOncohematology Unit, Maternal and Child Health Department, Pediatric Hematology, Oncology and Stem Cell Transplant Center, University of Padua School of Medicine, Padua, Italy.
Laura BonaldiImmunology and Molecular Oncology Unit, IRCSS Istituto Oncologico Veneto, Padua, Italy.
Fabrizio VianelloHematology and Clinical Immunology Unit, Department of Medicine - DIMED, University of Padua School of Medicine, Padua, Italy.
Claudio AgostinelliDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Maurilio PonzoniHaematopathology Diagnostic Area, Pathology Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Angelo Paolo Dei Tos *Surgical Pathology and Cytopathology Unit, Department of Medicine - DIMED, University of Padua School of Medicine, via A. Gabelli, 61, 35121, Padua, PD, Italy.
Elena Sabattini *Hematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
University of Padua · ITAzienda USL di Bologna · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITVita-Salute San Raffaele University · ITIstituto Oncologico Veneto · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) is a rare lymphoid neoplasm, usually occurring in the pediatric/young-adult age. Despite this, subsets of cases occur in elderly patients and express CD5, possibly entering the differential diagnosis with adult aggressive lymphomas, such as blastoid/pleomorphic mantle cell lymphoma (MCL-B/P). To better characterize the clinical-pathological features and differential diagnosis of LBCL-IRF4, we conducted a multi-centric study on 12 cases, focusing on CD5, Cyclin D1, and SOX11 expression. While most cases had typical presentation, adult-to-elderly age at diagnosis and unusual anatomic locations were reported in 3/12 (25.0%) and 2/12 (16.7%) patients, respectively. Histologically, CD5 was positive in 4/12 (33.3%) cases, Cyclin D1 was invariably negative, and SOX11 was weakly/partially expressed in 1/12 (8.3%) case. In conclusion, LBCL-IRF4 can have unconventional clinical presentations that may challenge its recognition. Although CD5 is frequently expressed, negativity for Cyclin D1 and SOX11 contributes to the differential diagnosis with MCL-B/P.

Indexed as

Lymphoma, Large B-Cell, DiffuseLymphoma, Mantle-CellAdultAgedChildCyclin D1Diagnosis, DifferentialHumansPhenotypeCyclin D1Cyclin D1Large B-cell lymphoma with IRF4 rearrangementMantle cell lymphomaPediatric lymphomaSOX11

Identifiers

PMID37962684
OpenAlexW4388654164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.