Evidence map›Paper›PMID 37962666›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2024

Widefield swept-source optical coherence tomography angiography metrics associated with neovascular glaucoma in patients with proliferative diabetic retinopathy.

Edward S Lu, Ying Cui, Rongrong Le, Ying Zhu, Jay C Wang, Inês Laíns, Raviv Katz, Yifan Lu, Rebecca Zeng, Itika Garg and 4 more

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Edward S LuHarvard Retinal Imaging Lab, Boston, MA, USA.
Ying CuiHarvard Retinal Imaging Lab, Boston, MA, USA.
Rongrong LeHarvard Retinal Imaging Lab, Boston, MA, USA.
Ying ZhuHarvard Retinal Imaging Lab, Boston, MA, USA.
Jay C WangHarvard Retinal Imaging Lab, Boston, MA, USA.
Inês LaínsHarvard Retinal Imaging Lab, Boston, MA, USA.
Raviv KatzHarvard Retinal Imaging Lab, Boston, MA, USA.
Yifan LuHarvard Retinal Imaging Lab, Boston, MA, USA.
Rebecca ZengHarvard Retinal Imaging Lab, Boston, MA, USA.
Itika GargHarvard Retinal Imaging Lab, Boston, MA, USA.
David M WuDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Deeba HusainDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Leo A KimDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA.
John B MillerHarvard Retinal Imaging Lab, Boston, MA, USA. john_miller@meei.harvard.edu.ORCID http://orcid.org/0000-0003-0109-9738
Massachusetts Eye and Ear Infirmary · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo explore the association between widefield swept-source optical coherence tomography angiography (WF SS-OCTA) metrics, including nonperfusion area (NPA) and neovascularization (NV), and presence of neovascular glaucoma (NVG) in patients with proliferative diabetic retinopathy (PDR).

methodsA prospective, cross-sectional study was conducted from November 2018 to February 2020. A total of 85 eyes of 60 PDR patients without NVG and 9 eyes of 8 PDR patients with NVG were included. Retinal ischemic parameters (NPA; ischemia index [NPA/total retinal area]) and NV features (NV number; NV area; NV vessel density) were evaluated. Foveal avascular zone (FAZ), macular thickness/volume, and choroidal thickness/volume were obtained using the Zeiss ARI Network. WF SS-OCTA retinal and choroidal metrics, systemic, and ocular parameters were screened using Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression for variable selection. Firth's bias-reduced logistic regression (outcome: presence of NVG) was subsequently used to identify parameters associated with NVG.

resultsAfter LASSO variable selection, 8 variables were significantly associated with the presence of NVG: DM duration (years), insulin (yes/no), best-corrected visual acuity (BCVA) (logMAR), IOP, ischemia index, skeletonized vessel density, macular thickness (inner inferior, outer temporal regions). Firth's bias-reduced logistic regression showed ischemia index (odds ratio [OR]=13.2, 95% confidence interval [CI]:5.3-30.7, P<0.001) and BCVA (OR=5.8, 95%CI:1.2-28.8, P<0.05) were associated with the presence of NVG. NV metrics, FAZ, and choroidal parameters were not related to NVG.

conclusionsRetinal ischemia but not NV was associated with the presence of NVG in patients with PDR using WF SS-OCTA. Larger, longitudinal studies are needed to validate imaging biomarkers associated with diabetic NVG.

Indexed as

Diabetes MellitusDiabetic RetinopathyGlaucoma, NeovascularCross-Sectional StudiesFluorescein AngiographyHumansIschemiaNeovascularization, PathologicProspective StudiesRetinal VesselsTomography, Optical CoherenceNeovascular glaucomaNeovascularizationProliferative diabetic retinopathySwept-source optical coherence tomography angiography

Identifiers

PMID37962666
OpenAlexW4388657646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.