Evidence map›Paper›PMID 37962355›Full record

ArticleJournal of virology2023

Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress.

Nathan R Zemke, Emily Hsu, William D Barshop, Jihui Sha, James A Wohlschlegel, Arnold J Berk

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nathan R ZemkeMolecular Biology Institute, University of California, Los Angeles, California, USA.ORCID 0000-0002-6326-5925
Emily HsuMolecular Biology Institute, University of California, Los Angeles, California, USA.ORCID 0000-0001-5096-0745
William D BarshopThermo Fisher Scientific, San Jose, California, USA.
Jihui ShaThermo Fisher Scientific, San Jose, California, USA.
James A WohlschlegelMolecular Biology Institute, University of California, Los Angeles, California, USA.
Arnold J BerkMolecular Biology Institute, University of California, Los Angeles, California, USA.
University of California, Los Angeles · USThermo Fisher Scientific (United States) · USUSC Norris Comprehensive Cancer Center · US

Funding

Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
NIGMS NIH HHS R01 GM089778
6 · The paper itself

Abstract

importanceInactivation of EP300/CREBB paralogous cellular lysine acetyltransferases (KATs) during the early phase of infection is a consistent feature of DNA viruses. The cell responds by stabilizing transcription factor IRF3 which activates transcription of scores of interferon-stimulated genes (ISGs), inhibiting viral replication. Human respiratory adenoviruses counter this by assembling a CUL4-based ubiquitin ligase complex that polyubiquitinylates RUVBL1 and 2 inducing their proteasomal degradation. This inhibits accumulation of active IRF3 and the expression of anti-viral ISGs, allowing replication of the respiratory HAdVs in the face of inhibition of EP300/CBEBBP KAT activity by the N-terminal region of E1A.

Indexed as

Adenovirus E1A ProteinsATPases Associated with Diverse Cellular ActivitiesCarrier ProteinsDNA HelicasesImmunity, InnateProteasome Endopeptidase ComplexStress, PhysiologicalAdenoviruses, HumanCullin ProteinsE1A-Associated p300 ProteinHumansInterferon Regulatory Factor-3InterferonsProtein Structure, QuaternaryUbiquitinationUbiquitin-Protein Ligase ComplexesAdenovirus E1A ProteinsATPases Associated with Diverse Cellular ActivitiesCarrier ProteinsCUL4B protein, humanCullin ProteinsDNA HelicasesE1A-Associated p300 ProteinEP300 protein, humanInterferon Regulatory Factor-3InterferonsIRF3 protein, humanProteasome Endopeptidase ComplexRUVBL1 protein, humanRUVBL2 protein, humanUbiquitin-Protein Ligase ComplexesadenovirusCBPCRL4DCAF10E1Ainnate immunityIRF3P300virology

Identifiers

PMID37962355
PMCPMC10734532
OpenAlexW4388655692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.