ArticleCancer medicine2023
Optimal interval timing between transurethral resection of bladder tumors and Bacillus Calmette-Guerin perfusion.
Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Bladder mucosal apoptosis index and quality of life after adjuvant intravesical BCG therapy for non-muscle-invasive bladder cancer: a retrospective propensity-score-matched study.Frontiers in oncology · 2026Article
- Intravesical chemotherapy in BCG waiting period may prolong time to recurrence for high-risk NMIBC patients.BMC cancer · 2025Article
- Repeat TURBT in large volume high-grade non-invasive bladder cancer.Bladder cancer (Amsterdam, Netherlands) · 2024Article
- Optimal interval timing between transurethral resection of bladder tumors and Bacillus Calmette-Guerin perfusion.Cancer medicine · 2023Article
- A risk-adapted approach to reTURBT in high-grade T1 NMIBC.Bladder cancer (Amsterdam, Netherlands)Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveThere is no consensus regarding the best interval time between transurethral resection of a bladder tumor and Bacillus Calmette-Guerin (BCG) perfusion. This study was to explore whether the interval time has an impact on the prognosis and adverse effects.
methodsWe retrospectively reviewed the clinical data of patients who received BCG intravesical perfusion at Sun Yat-sen University Cancer Center (SYSUCC) from September 2015 to October 2021. Recurrence-free survival (RFS) and progression-free survival were the primary endpoints. Cox regression was used to explore independent predictors. The association between interval time and adverse effect grade was detected by logistic regression. Propensity score matching (PSM) was performed.
resultsA total of 403 patients were enrolled, the median interval time was 24 days (6-163 days), and the follow-up was 28 months (7-82 months). Eighty-eight (20.9%) patients relapsed, and 40 patients (10.0%) suffered progression. The multivariate Cox regression analysis confirmed that interval time was an independent predictor of RFS (p = 0.017). Notably, when the interval time was less than or equal to 26 days, there was a trend toward better RFS, PSM resulted in 65 matched pairs in each group, and Kaplan-Meier analysis showed that there was a significant difference in RFS between groups (p = 0.009). The logistic regression analysis showed that there was no correlation between interval time and adverse effects and their grades (p > 0.05).
conclusionsWe considered that the first BCG perfusion could be performed within 2-4 weeks after surgery.
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