Evidence map›Paper›PMID 37962199›Full record

ReviewCancer2024

Fertility preservation before and after cancer treatment in children, adolescents, and young adults.

Emily H Yang, Harmonie B Strohl, H Irene Su

Open access · bronzeAbstract readReview
In one paragraph

Review in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  12. Observational
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  17. Review
  18. Fertility preservation decision-making among adolescents and young adults with hematologic diseases and their families in China: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  19. Challenges in fertility preservation among patients with cancer in Iran: A scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily H YangDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego, La Jolla, California, USA.
Harmonie B StrohlSchool of Medicine, University of California, San Diego, La Jolla, California, USA.
H Irene SuDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
University of California San Diego · US

Funding

Evaluation of a telehealth oncofertility care intervention in adolescent and young adult cancer patients: a stepped wedge cluster randomized controlled trialR01CA271104 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hui-Chun Irene Su · 2023 to 2026
$2.6M
Policy implementation research on health benefit mandates for fertility preservation services to improve access to care in young cancer survivorsR21CA271184 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCMENAMIN, SARA BLYTHE, SU, HUI-CHUN IRENE · 2022 to 2023
$403k
NCI NIH HHS R01 CA271104NCI NIH HHS R01CA271104NCI NIH HHS R21 CA271184NCI NIH HHS R21CA271184
6 · The paper itself

Abstract

Fertility is a top concern for many survivors of cancer diagnosed as children, adolescents and young adults (CAYA). Fertility preservation (FP) treatments are effective, evidence-based interventions to support their family building goals. Fertility discussions are a part of quality oncology care throughout the cancer care continuum. For nearly 2 decades, clinical guidelines recommend counseling patients about the possibility of infertility promptly at diagnosis and offering FP options and referrals as indicated. Multiple guidelines now recommend post-treatment counseling. Infertility risks differ by cancer treatments and age, rendering risk stratification a central part of FP care. To support FP decision-making, online tools for female risk estimation are available. At diagnosis, females can engage in mature oocyte/embryo cryopreservation, ovarian tissue cryopreservation, ovarian suppression with GnRH agonists, in vitro oocyte maturation, and/or conservative management for gynecologic cancers. Post-treatment, several populations may consider undergoing oocyte/embryo cryopreservation. Male survivors' standard of care FP treatments center on sperm cryopreservation before cancer treatment and do not have the same post-treatment indication for additional gamete cryopreservation. In practice, FP care requires systemized processes to routinely screen for FP needs, bridge oncology referrals to fertility, offer timely fertility consultations and access to FP treatments, and support financial navigation. Sixteen US states passed laws requiring health insurers to provide insurance benefits for FP treatments, but variation among the laws and downstream implementation are barriers to accessing FP treatments. To preserve the reproductive futures of CAYA survivors, research is needed to improve risk stratification, FP options, and delivery of FP care.

Indexed as

Fertility PreservationGenital Neoplasms, FemaleInfertilityNeoplasmsAdolescentChildCryopreservationFemaleHumansMaleSemenYoung Adultadolescent and young adult cancercancer survivorshipchildhood cancerfertility preservationreproductive health

Identifiers

PMID37962199
PMCPMC10841998
OpenAlexW4388657350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.