Evidence map›Paper›PMID 37961741›Full record

ArticleArXiv2024

Computational and Systems Biology Advances to Enable Bioagent Agnostic Signatures.

Andy Lin, Cameron Torres, Errett C Hobbs, Jaydeep Bardhan, Stephen Aley, Charles T Spencer, Karen L Taylor, Tony Chiang

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Andy LinNational Security Directorate, Pacific Northwest National Laboratory, Seattle, WA 98109, USA.
Cameron TorresDepartment of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968 USA.
Errett C HobbsNational Security Directorate, Pacific Northwest National Laboratory, Seattle, WA 98109, USA.
Jaydeep BardhanEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Seattle, WA 98109, USA.
Stephen AleyDepartment of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968 USA.
Charles T SpencerDepartment of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968 USA.
Karen L TaylorNational Security Directorate, Pacific Northwest National Laboratory, Seattle, WA 98109, USA.
Tony ChiangNational Security Directorate, Pacific Northwest National Laboratory, Seattle, WA 98109, USA.

Funding

NKT cell subsets modulate systemic inflammationSC1AI148753 · NIAID · UNIVERSITY OF TEXAS EL PASO · PI SPENCER, CHARLES THOMAS · 2019 to 2022
$1.5M
NIAID NIH HHS SC1 AI148753
6 · The paper itself

Abstract

Enumerated threat agent lists have long driven biodefense priorities. The global SARS-CoV-2 pandemic demonstrated the limitations of searching for known threat agents as compared to a more agnostic approach. Recent technological advances are enabling agent-agnostic biodefense, especially through the integration of multi-modal observations of host-pathogen interactions directed by a human immunological model. Although well-developed technical assays exist for many aspects of human-pathogen interaction, the analytic methods and pipelines to combine and holistically interpret the results of such assays are immature and require further investments to exploit new technologies. In this manuscript, we discuss potential immunologically based bioagent-agnostic approaches and the computational tool gaps the community should prioritize filling.

Identifiers

PMID37961741
PMCPMC10635321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.