Evidence map›Paper›PMID 37961706›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Pamela E Rios Coronado, Daniela Zanetti, Jiayan Zhou, Jeffrey A Naftaly, Pratima Prabala, Azalia M Martínez Jaimes, Elie N Farah, Xiaochen Fan, Soumya Kundu, Salil S Deshpande and 20 more

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 10 institutions in 3 countries.

Pamela E Rios CoronadoDepartment of Biology, Stanford University; Stanford, CA, USA.ORCID 0000-0003-4665-6438
Daniela ZanettiDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0002-1225-1021
Jiayan ZhouVA Palo Alto Health Care System; Palo Alto, CA, USA.ORCID 0000-0001-5974-087X
Jeffrey A NaftalyDepartment of Biology, Stanford University; Stanford, CA, USA.ORCID 0000-0002-8981-0063
Pratima PrabalaDepartment of Biology, Stanford University; Stanford, CA, USA.ORCID 0000-0001-6436-6907
Azalia M Martínez JaimesDepartment of Developmental Biology, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0001-9412-6787
Elie N FarahDepartment of Medicine, Division of Cardiology, University of California San Diego; La Jolla, CA, USA.ORCID 0000-0002-2412-0950
Xiaochen FanDepartment of Biology, Stanford University; Stanford, CA, USA.ORCID 0000-0002-4316-0616
Soumya KunduDepartment of Genetics, Stanford University School of Medicine; Stanford, CA, USA.
Salil S DeshpandeInstitute for Computational and Mathematical Engineering, Stanford University School of Medicine; Stanford, CA, USA.
Ivy EvergreenDepartment of Genetics, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0009-0004-6737-889X
Pik Fang KhoDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0001-7831-6062
Austin T HilliardVA Palo Alto Health Care System; Palo Alto, CA, USA.ORCID 0000-0002-1289-4377
Sarah AbramowitzDepartment of Medicine, Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine; Philadelphia, PA, USA.ORCID 0000-0001-5515-1752
Saiju PyarajanCenter for Data and Computational Sciences, VA Boston Healthcare System; Boston, MA, USA.
Daniel DochtermannCenter for Data and Computational Sciences, VA Boston Healthcare System; Boston, MA, USA.ORCID 0000-0001-9513-5124
Million Veteran Program
Scott M DamrauerCorporal Michael J. Crescenz VA Medical Center; Philadelphia, PA, USA.ORCID 0000-0001-8009-1632
Kyong-Mi ChangCorporal Michael J. Crescenz VA Medical Center; Philadelphia, PA, USA.ORCID 0000-0001-6811-9364
Michael G LevinDepartment of Medicine, Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine; Philadelphia, PA, USA.ORCID 0000-0002-9937-9932
Virginia D WinnDepartment of Obstetrics and Gynecology, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0003-1136-2907
Anca M PaşcaDepartment of Pediatrics, Neonatology, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0002-0445-9009
Mary E PlomondonDepartment of Medicine, Rocky Mountain Regional VA Medical Center; Aurora, CO, USA.ORCID 0000-0002-8616-4916
Stephen W WaldoDepartment of Medicine, Rocky Mountain Regional VA Medical Center; Aurora, CO, USA.ORCID 0000-0003-0678-4873
Philip S TsaoVA Palo Alto Health Care System; Palo Alto, CA, USA.ORCID 0000-0001-7274-9318
Anshul KundajeDepartment of Genetics, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0003-3084-2287
Neil C ChiDepartment of Medicine, Division of Cardiology, University of California San Diego; La Jolla, CA, USA.ORCID 0000-0003-2324-3796
Shoa L ClarkeDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0002-6592-1172
Kristy Red-HorseDepartment of Biology, Stanford University; Stanford, CA, USA.ORCID 0000-0003-1541-601X
Themistocles L AssimesDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0003-2349-0009
VA Palo Alto Health Care System · USStanford University · USPhiladelphia VA Medical Center · USStanford Medicine · USRocky Mountain MS Center · USUniversity of California San Diego · USVA Boston Healthcare System · USDonald & Barbara Zucker School of Medicine at Hofstra/Northwell · USHoward Hughes Medical Institute · USInstitute of Mathematical Statistics · US

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Institutional Career Development Core (KL2)KL2TR003143 · NCATS · STANFORD UNIVERSITY · PI ASCH, STEVEN M. · 2019 to 2023
$8.7M
Mechanotransduction and transcriptional regulation during artery developmentR01HL128503 · NHLBI · STANFORD UNIVERSITY · PI Mary Red-Horse · 2015 to 2026
$5.8M
Training in Myocardial Biology at Stanford (TIMBS)T32HL094274 · NHLBI · STANFORD UNIVERSITY · PI Euan A Ashley, Daniel Bernstein · 2010 to 2026
$5.0M
Genetics of Cardiometabolic Diseases in the VA PopulationI01BX003362 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Kyong-Mi Chang, Philip S Tsao · 2017 to 2026
–
BLRD VA I01 BX003362NCATS NIH HHS KL2 TR003143NCATS NIH HHS UL1 TR001878NHLBI NIH HHS R01 HL128503NHLBI NIH HHS T32 HL007444NHLBI NIH HHS T32 HL094274NIGMS NIH HHS T32 GM007276
6 · The paper itself

Abstract

To efficiently distribute blood flow to cardiac muscle, the coronary artery tree must follow a specific branching pattern over the heart. How this pattern arises in humans is unknown due to the limitations of studying human heart development. Here, we leveraged a natural variation of coronary artery anatomy, known as coronary dominance, in genetic association studies to identify the first known driver of human coronary developmental patterning. Coronary dominance refers to whether the right, left, or both coronary arteries branch over the posterior left ventricle, but whether this variability is heritable and how it would be genetically regulated was completely unknown. By conducting the first large-scale, multi-ancestry genome-wide association study (GWAS) of coronary dominance in 61,043 participants of the VA Million Veteran Program, we observed moderate heritability (27.7%) with ten loci reaching genome wide significance. An exceptionally strong association mapped DNA variants to a non-coding region near the chemokine

Identifiers

PMID37961706
PMCPMC10635223
OpenAlexW4387977079

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.