Evidence map›Paper›PMID 37961701›Full record

ArticlebioRxiv : the preprint server for biology2023

Gene expression analyses reveal differences in children's response to malaria according to their age.

Kieran Tebben, Salif Yirampo, Drissa Coulibaly, Abdoulaye K Koné, Matthew B Laurens, Emily M Stucke, Ahmadou Dembélé, Youssouf Tolo, Karim Traoré, Amadou Niangaly and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 2 countries.

Kieran TebbenInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-8866-7667
Salif YirampoMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.ORCID 0000-0002-6510-2548
Drissa CoulibalyMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.ORCID 0000-0002-7412-0940
Abdoulaye K KonéMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.
Matthew B LaurensMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, USA.ORCID 0000-0003-3874-581X
Emily M StuckeMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, USA.ORCID 0000-0002-8256-3290
Ahmadou DembéléMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.
Youssouf ToloMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.
Karim TraoréMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.
Amadou NiangalyMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.ORCID 0000-0003-3768-8446
Andrea A BerryMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, USA.ORCID 0000-0003-3140-3868
Bourema KouribaMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.ORCID 0000-0002-3419-5972
Christopher V PloweMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, USA.
Ogobara K DoumboMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.
Kirsten E LykeMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, USA.ORCID 0000-0002-4966-0830
Shannon Takala-HarrisonMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, USA.ORCID 0000-0003-4674-8500
Mahamadou A TheraMalaria Research and Training Center, University of Sciences, Techniques and Technologies; Bamako, Mali.
Mark A TravassosMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine; Baltimore, USA.ORCID 0000-0002-6045-3322
David SerreInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2446-9095
University of Bamako · MLUniversity of Maryland, Baltimore · US

Funding

Signaling Pathways in Innate ImmunityT32AI095190 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Stefanie N. Vogel · 2012 to 2026
$4.7M
Genetic diversity and protective immunity to malaria infection and diseaseU01AI065683 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PLOWE, CHRISTOPHER V. · 2010 to 2014
$3.0M
MALARIA RESEARCH TRAINING IN MALID43TW001589 · FIC · UNIVERSITY OF MARYLAND BALTIMORE · PI PLOWE, CHRISTOPHER V. · 2000 to 2015
$2.8M
Variant surface antigens in cerebral malaria pathogenesisR01HL130750 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI FISHER, STEVEN A., HARRISON, SHANNON TAKALA · 2015 to 2018
$2.1M
Malaria variant surface antigen expression and vulnerability to disease in Malian children with Hemoglobin C traitR01HL146377 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TRAVASSOS, MARK A · 2019 to 2023
$1.9M
Protein microarray antibody responses to P. falciparum in a human challenge modelK23AI125720 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BERRY, ANDREA · 2017 to 2021
$915k
Host vulnerability and parasite genetics in the development of cerebral malariaR01AI099628 · NIAID · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI THERA, MAHAMADOU ALI · 2014 to 2018
$625k
Host and Parasite Transcriptional Changes Associated with Immunity to Clinical Malaria in Malian ChildrenR21AI146853 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SERRE, DAVID, TRAVASSOS, MARK A · 2019 to 2020
$425k
FIC NIH HHS D43 TW001589NHLBI NIH HHS R01 HL130750NHLBI NIH HHS R01 HL146377NIAID NIH HHS K23 AI125720NIAID NIH HHS R01 AI099628NIAID NIH HHS R21 AI146853NIAID NIH HHS T32 AI095190NIAID NIH HHS U01 AI065683
6 · The paper itself

Abstract

In Bandiagara, Mali, children experience on average two clinical malaria episodes per season. However, even in the same transmission area, the number of uncomplicated symptomatic infections, and their parasitemia, vary dramatically among children. To examine the factors contributing to these variations, we simultaneously characterized the host and parasite gene expression profiles from 136 children with symptomatic falciparum malaria and analyzed the expression of 9,205 human and 2,484

Identifiers

PMID37961701
PMCPMC10634788
OpenAlexW4387957396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.