Evidence map›Paper›PMID 37961697›Full record

ArticlebioRxiv : the preprint server for biology2024

Critical role of CD206+ macrophages in promoting a cDC1-NK-CD8 T cell anti-tumor immune axis.

Arja Ray, Kenneth H Hu, Kelly Kersten, Tristan Courau, Nicholas F Kuhn, Itzia Zaleta-Linares, Bushra Samad, Alexis J Combes, Matthew F Krummel

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Arja RayDepartment of Pathology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-2305-2324
Kenneth H HuDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Kelly KerstenDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Tristan CourauDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Nicholas F KuhnDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Itzia Zaleta-LinaresDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Bushra SamadImmunoX Initiative, University of California, San Francisco, CA 94143, USA.
Alexis J CombesDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Matthew F KrummelDepartment of Pathology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-7915-3533
University of California, San Francisco · US

Funding

Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
The Tumor Microenvironment Niche of Type I conventional Dendritic CellsR01CA197363 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2017 to 2026
$4.5M
CONTROL OF T CELL SYNAPSE STABILIZATION AND SIGNALINGR37AI052116 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2023 to 2026
$2.5M
NCI NIH HHS R01 CA197363NCI NIH HHS T32 CA108462NIAID NIH HHS R37 AI052116
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) are frequently categorized as being 'M1' or 'M2' polarized, even as substantial data challenges this binary modeling of macrophage cell state. One molecule consistently referenced as a delineator of a putative immunosuppressive 'M2' state is the surface protein CD206. We thus made a novel conditional CD206 (

Identifiers

PMID37961697
PMCPMC10635006
OpenAlexW4388234093

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.