Evidence map›Paper›PMID 37961696›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Accelerated biological aging six decades after prenatal famine exposure.

Mengling Cheng, Dalton Conley, Tom Kuipers, Chihua Li, Calen Ryan, Jazmin Taubert, Shuang Wang, Tian Wang, Jiayi Zhou, Lauren L Schmitz and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Mengling ChengSwiss Centre of Expertise in Life Course Research, University of Lausanne, Lausanne, Switzerland.
Dalton ConleyDepartment of Sociology, Princeton University, Princeton, NJ, USA.
Tom KuipersDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands.
Chihua LiInstitute for Social Research, University of Michigan at Ann Arbor, Ann Arbor, MI, USA.
Calen RyanRobert N. Butler Columbia Aging Center, Columbia University, New York, NY, USA.
Jazmin TaubertDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands.
Shuang WangDepartment of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, USA.
Tian WangDepartment of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, USA.
Jiayi ZhouRobert N. Butler Columbia Aging Center, Columbia University, New York, NY, USA.
Lauren L SchmitzRobert M. La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI, USA.
Elmar W TobiDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands.
Bas HeijmansDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands.
L H LumeyDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands.
Daniel W BelskyRobert N. Butler Columbia Aging Center, Columbia University, New York, NY, USA.
Columbia University · USLeiden University Medical Center · NLFORS – Swiss Centre of Expertise in the Social Sciences · CHPrinceton University · USUniversity of Michigan · USUniversity of Wisconsin–Madison · US

Funding

Genetic analysis of the Dutch Hunger Winter Families Study to Boost Rigor and Robustness for Testing In-Utero Famine Effects on Aging-Related Health Conditions and Biological AgingR01AG066887 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BELSKY, DANIEL WALKER, LUMEY, L H · 2020 to 2024
$3.5M
Prenatally induced DNA methylation profiles and disease risk at age 60R01AG042190 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LUMEY, L H · 2011 to 2013
$989k
Life Course Determinants of Epigenetic Age Acceleration and Subsequent DementiaR00AG056599 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SCHMITZ, LAUREN LUCIA · 2019 to 2021
$738k
NIA NIH HHS R00 AG056599NIA NIH HHS R01 AG042190NIA NIH HHS R01 AG066887
6 · The paper itself

Abstract

To test the hypothesis that early-life adversity accelerates the pace of biological aging, we analyzed data from the Dutch Hunger Winter Families Study (DHWFS, N=951). DHWFS is a natural-experiment birth-cohort study of survivors of in-utero exposure to famine conditions caused by the German occupation of the Western Netherlands in Winter 1944-5, matched controls, and their siblings. We conducted DNA methylation analysis of blood samples collected when the survivors were aged 58 to quantify biological aging using the DunedinPACE, GrimAge, and PhenoAge epigenetic clocks. Famine survivors had faster DunedinPACE, as compared with controls. This effect was strongest among women. Results were similar for GrimAge, although effect-sizes were smaller. We observed no differences in PhenoAge between survivors and controls. Famine effects were not accounted for by blood-cell composition and were similar for individuals exposed early and later in gestation. Findings suggest in-utero undernutrition may accelerate biological aging in later life.

Indexed as

biological agingearly-life adversityfamine/undernutritionnatural experimentprenatal exposure

Identifiers

PMID37961696
PMCPMC10635274
OpenAlexW4388330324

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.