ArticlebioRxiv : the preprint server for biology2025
Loss of CTRP10 results in female obesity with preserved metabolic health.
Fangluo Chen, Dylan C Sarver, Muzna Saqib, Leandro M Velez, Susan Aja, Marcus M Seldin, G William Wong
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors at 2 institutions in 1 country.
Fangluo ChenDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dylan C SarverDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Muzna SaqibDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Leandro M VelezDepartment of Biological Chemistry, University of California, Irvine, Irvine, USA.
Susan AjaCenter for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Marcus M SeldinDepartment of Biological Chemistry, University of California, Irvine, Irvine, USA.
G William WongDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5286-6506 Johns Hopkins University · USUniversity of California, Irvine · US
Funding
UM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MMULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3MPUBLIC HEALTH DEMONSTRATIONP60DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1985 to 2012
$26.5MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MCTRP and Metabolic ControlR01DK084171 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Guang William Wong · 2010 to 2026
$8.0MMETABOLIC IMPACTS OF TYPE II INTERFERON SIGNALS IN OBESITYR01DK114356 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2017 to 2025
$4.6MMetabolic Phenotyping in Live Models of Obesity and DiabetesU2CDK135066 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias · 2023 to 2026
$3.5MIntegrative approaches to dissection of endocrine communicationDP1DK130640 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SELDIN, MARCUS MICHAEL · 2021 to 2025
$3.2MA strategy for discovery of endocrine interactionsR00HL138193 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SELDIN, MARCUS MICHAEL · 2020 to 2022
$745kDevelopment of a strategy for endocrine axis discoveryK99HL138193 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SELDIN, MARCUS MICHAEL · 2018 to 2019
$268kNHGRI NIH HHS UM1 HG006348NHLBI NIH HHS K99 HL138193NHLBI NIH HHS R00 HL138193NHLBI NIH HHS T32 HL007534NIDDK NIH HHS DP1 DK130640NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P60 DK020572NIDDK NIH HHS R01 DK084171NIDDK NIH HHS R01 DK114356NIDDK NIH HHS U2C DK135066
6 · The paper itselfAbstract
Obesity is a major risk factor for type 2 diabetes, dyslipidemia, cardiovascular disease, and hypertension. Intriguingly, there is a subset of metabolically healthy obese (MHO) individuals who are seemingly able to maintain a healthy metabolic profile free of metabolic syndrome. The molecular underpinnings of MHO, however, are not well understood. Here, we report that CTRP10/C1QL2-deficient mice represent a unique female model of MHO. CTRP10 modulates weight gain in a striking and sexually dimorphic manner. Female, but not male, mice lacking CTRP10 develop obesity with age on a low-fat diet while maintaining an otherwise healthy metabolic profile. When fed an obesogenic diet, female
Indexed as
DiabetesMetabolically Healthy Obese (MHO)MetabolismObesity
Identifiers
PMID37961647
PMCPMC10635050
OpenAlexW4388336939
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LicenceCC BY
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