Evidence map›Paper›PMID 37961644›Full record

ArticlebioRxiv : the preprint server for biology2024

SPARK regulates AGC kinases central to the

Alice L Herneisen, Michelle L Peters, Tyler A Smith, Emily Shortt, Sebastian Lourido

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Alice L HerneisenWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.ORCID 0000-0003-3368-0893
Michelle L PetersWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.ORCID 0000-0002-2919-2523
Tyler A SmithWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.ORCID 0000-0002-3399-4043
Emily ShorttWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.ORCID 0009-0009-7625-4772
Sebastian LouridoWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.ORCID 0000-0002-5237-1095

Funding

Development and maintenance of chronic toxoplasmosisR01AI158501 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2021 to 2025
$3.3M
Control of parasite invasion by a microneme protein complex conserved in ApicomplexansR01AI144369 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2020 to 2024
$2.4M
NIAID NIH HHS R01 AI144369NIAID NIH HHS R01 AI158501
6 · The paper itself

Abstract

Apicomplexan parasites balance proliferation, persistence, and spread in their metazoan hosts. AGC kinases, such as PKG, PKA, and the PDK1 ortholog SPARK, integrate environmental signals to toggle parasites between replicative and motile life stages. Recent studies have cataloged pathways downstream of apicomplexan PKG and PKA; however, less is known about the global integration of AGC kinase signaling cascades. Here, conditional genetics coupled to unbiased proteomics demonstrates that SPARK complexes with an elongin-like protein to regulate the stability of PKA and PKG in the model apicomplexan

Identifiers

PMID37961644
PMCPMC10634940

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.